Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 GeneticVariation disease BEFREE Genetic variation in ALCAM and other chromosomal instability genes in breast cancer survival. 21935604 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 GeneticVariation group BEFREE As of now, various CSC functions and marker genes have been identified due to the heterogeneity of cancer, such as aldehyde dehydrogenase (ALDH), the second member of the ABC transporter G-subfamily (ABCG2), activated leukocyte cell adhesion molecule (ALCAM) and CD133. 29808880 2018
CUI: C0025303
Disease: Meningococcal Infections
Meningococcal Infections 		0.100 GeneticVariation group GWASDB Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. 20694013 2010
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 GeneticVariation phenotype BEFREE To test this hypothesis, we examined an under-explored ALCAM splice variant (ALCAM-Iso2) and demonstrated that loss of the membrane-proximal region of ALCAM (exon 13) increased metastasis four-fold. 29453336 2018
CUI: C0596887
Disease: mathematical ability
mathematical ability 		0.100 GeneticVariation phenotype GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 GeneticVariation disease BEFREE Genetic variation in ALCAM and other chromosomal instability genes in breast cancer survival. 21935604 2012
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 GeneticVariation group BEFREE As of now, various CSC functions and marker genes have been identified due to the heterogeneity of cancer, such as aldehyde dehydrogenase (ALDH), the second member of the ABC transporter G-subfamily (ABCG2), activated leukocyte cell adhesion molecule (ALCAM) and CD133. 29808880 2018
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation phenotype GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.080 GeneticVariation disease LHGDN Over the past decade, alterations in expression of ALCAM have been reported in several human tumors (melanoma, prostate cancer, breast cancer, colorectal carcinoma, bladder cancer, and esophageal squamous cell carcinoma). 18279810 2008
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.050 GeneticVariation disease BEFREE The present study is the first to report evidence of the association of rs6437585 ALCAM polymorphism with risk and progression of MS. Our investigation revealed that rs6437585CT individuals had higher risk of MS (OR=2.34; 95%CI=1.22-4.51; P=0.011) and over 2 years earlier age of onset (95%CI=0.16-4.41, P=0.036). 23507476 2013
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 GeneticVariation group LHGDN Activated leukocyte cell adhesion molecule: a new paradox in cancer. 18279810 2008
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.040 GeneticVariation disease BEFREE Hotspot <i>KRAS</i> exon 2 mutations in CD166 positive colorectal cancer and colorectal adenoma cells. 29755662 2018
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.030 GeneticVariation disease LHGDN Over the past decade, alterations in expression of ALCAM have been reported in several human tumors (melanoma, prostate cancer, breast cancer, colorectal carcinoma, bladder cancer, and esophageal squamous cell carcinoma). 18279810 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.020 GeneticVariation group LHGDN Activated leukocyte cell adhesion molecule: a new paradox in cancer. 18279810 2008
CUI: C0002871
Disease: Anemia
Anemia 		0.010 GeneticVariation disease BEFREE The association between baseline plasma levels of soluble CD163 (sCD163), macrophage migration inhibitory factor (MIF), granulysin, soluble interleukin-2 receptor (sIL-2R), and activated leukocyte cell adhesion molecule (ALCAM) and the primary endpoint of death from any cause or first hospitalization for worsening of HF was evaluated using multivariable Cox proportional hazard models in 1541 patients with systolic HF and mild to moderate anemia, enrolled in the Reduction of Events by darbepoetin alfa in Heart Failure (RED-HF) trial. 30051179 2019
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.010 GeneticVariation group LHGDN Activated leukocyte cell adhesion molecule: a new paradox in cancer. 18279810 2008
CUI: C0018801
Disease: Heart failure
Heart failure 		0.010 GeneticVariation disease BEFREE The association between baseline plasma levels of soluble CD163 (sCD163), macrophage migration inhibitory factor (MIF), granulysin, soluble interleukin-2 receptor (sIL-2R), and activated leukocyte cell adhesion molecule (ALCAM) and the primary endpoint of death from any cause or first hospitalization for worsening of HF was evaluated using multivariable Cox proportional hazard models in 1541 patients with systolic HF and mild to moderate anemia, enrolled in the Reduction of Events by darbepoetin alfa in Heart Failure (RED-HF) trial. 30051179 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.010 GeneticVariation disease BEFREE The association between baseline plasma levels of soluble CD163 (sCD163), macrophage migration inhibitory factor (MIF), granulysin, soluble interleukin-2 receptor (sIL-2R), and activated leukocyte cell adhesion molecule (ALCAM) and the primary endpoint of death from any cause or first hospitalization for worsening of HF was evaluated using multivariable Cox proportional hazard models in 1541 patients with systolic HF and mild to moderate anemia, enrolled in the Reduction of Events by darbepoetin alfa in Heart Failure (RED-HF) trial. 30051179 2019
CUI: C0153452
Disease: Malignant neoplasm of gallbladder
Malignant neoplasm of gallbladder 		0.010 GeneticVariation disease BEFREE ALCAM Ars1157Crs10511244 (P = 0.0035) haplotype was significantly associated with GBC susceptibility. 26318430 2016
CUI: C0155880
Disease: Intrinsic asthma
Intrinsic asthma 		0.010 GeneticVariation disease BEFREE Borderline significant results (2.5 × 10(-7) < p <8.2 × 10(-7)) were observed between three single nucleotide polymorphisms (SNPs) in the ALCAM region (3q13.11) and "active adult-onset nonallergic asthma". 24311777 2014
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma 		0.010 GeneticVariation disease BEFREE ALCAM Ars1157Crs10511244 (P = 0.0035) haplotype was significantly associated with GBC susceptibility. 26318430 2016
CUI: C0243038
Disease: Carcinoma, Lewis Lung
Carcinoma, Lewis Lung 		0.010 GeneticVariation disease BEFREE Similarly, when LLC cells were implanted subcutaneously for the study of spontaneous tumor cell metastasis, the rate of LLC metastasis to the lungs was profoundly reduced in ALCAM<sup>-/-</sup> mice. 28822802 2017
CUI: C4523846
Disease: MSI-high
MSI-high 		0.010 GeneticVariation disease BEFREE Immunostainings for CD133, CD44, and CD166, and K-ras mutation analysis were performed on 50 MSI-high (MSI-H), and 50 microsatellite stable (MSS) CRC tissues. 23065858 2014
CUI: C4525297
Disease: Stage 0 Gallbladder Cancer AJCC v8
Stage 0 Gallbladder Cancer AJCC v8 		0.010 GeneticVariation disease BEFREE ALCAM Ars1157Crs10511244 (P = 0.0035) haplotype was significantly associated with GBC susceptibility. 26318430 2016