Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
EZH2 was identified as a direct target gene of miR-137 in U2OS cells by luciferase reporter assay and EZH2 expression was found to be significantly increased in OS tissues and cell lines (P<0.01).
|
28587390 |
2017 |
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, EZH2 is highly expressed and associated with the 3' end region of lncRNA MALAT1 in osteosarcoma, and this association finally suppressed the expression of E-cadherin.
|
28388584 |
2017 |
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, mechanistic analysis revealed that Xist can repress P21 expression to regulate OS cell cycle and proliferation by binding to EZH2.
|
29254174 |
2017 |
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, FOXP4-AS1 participates in the development and progression of OS by downregulating LATS1 via binding to LSD1 and EZH2.
|
29859193 |
2018 |
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, LINC01116 is involved in the development of osteosarcoma by binding to EZH2 to regulate expressions of PTEN and p53.
|
31486480 |
2019 |
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis indicated that EZH2 expression was significantly associated with more aggressive tumor behavior and poorer patient outcomes of osteosarcoma.
|
27223261 |
2016 |
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results showed that TUG1 plays an important role in osteosarcoma development through miRNA-144-3p/EZH2/Wnt/β-catenin pathway.
|
28902349 |
2017 |
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our study confirmed that HOXD-AS1 could interact with EZH2, and then repress p57 expression, to aggravate osteosarcoma oncogenesis. which provide new idea for the osteosarcoma tumorigenesis.
|
30119259 |
2018 |
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we reported that ectopic overexpression of miR-101 downregulated the expression level of EZH2 and significantly inhibited migration and invasion of osteosarcoma cells.
|
25190211 |
2014 |
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that EZH2 was abnormally elevated in osteosarcoma, and its overexpression was associated with poor prognosis in osteosarcoma.
|
26265454 |
2015 |
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
LncRNA-ANCR regulates the cell growth of osteosarcoma by interacting with EZH2 and affecting the expression of p21 and p27.
|
28679390 |
2017 |
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Long noncoding RNA LSINCT5 acts as an oncogene via increasing EZH2-induced inhibition of APC expression in osteosarcoma.
|
30420287 |
2018 |
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Most recently, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was found to play an important role in OS progression by modulating the enhancers of zeste homolog 2 (EZH2).
|
29290771 |
2018 |
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Prediction of response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles.
|
14767549 |
2004 |
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Proliferation, apoptosis assays and caspase-3 activity assay confirmed that elevated miR-138 expression enhanced osteosarcoma cell chemosensitivity to cisplatin by targeting EZH2.
|
27019355 |
2016 |
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Scientists consider EZH2 as an attractive target for the treatment of osteosarcoma and have found many potential EZH inhibitors, such as GlaxoSmithKline 343 (GSK343).
|
31651209 |
2020 |
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, for the first time, we provide convincing evidence that downregulation of miR-26a is associated with tumor aggressiveness and tumor metastasis, and miR-26a inhibits cell migration and invasion by targeting the EZH2 gene in osteosarcoma.
|
24452597 |
2014 |