Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma.
|
25605023 |
2015 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We detected EZH2 mutations in 12/55 (22%) follicular lymphomas (FL), 5/35 (14%) diffuse large B cell lymphomas with a germinal center immunophenotype (GCB-DLBCL), and 2/11 (18%) high grade B cell lymphomas with concurrent rearrangements of BCL2 and MYC.
|
22194861 |
2011 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL).
|
20104248 |
2010 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Germinal center-like DLBCL is enriched for activating EZH2 mutations, and encouraging activity has been observed for the EZH2 inhibitor tazemetostat, which now has a fast-track US Food and Drug Administration designation.
|
31287161 |
2019 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Next-generation sequencing of follicular lymphoma and diffuse-large B-cell lymphoma has revealed frequent somatic, heterozygous Y641 mutations in the histone methyltransferase EZH2.
|
21190999 |
2011 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The histone methyltransferase EZH2 is frequently mutated in germinal center-derived diffuse large B-cell lymphoma and follicular lymphoma.
|
24802772 |
2014 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We also identified multiple acquired mutations in EZH2 inhibitor-resistant DLBCL cell lines.
|
29572378 |
2018 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here, we discuss the function of histone acetyltransferases (CREBBP, EP300), histone methyltransferases (KDM2C/D, EZH2) and regulators of higher order chromatin structure (HIST1H1C/D/E, ARID1A and SMARCA4) that have been reported to be mutated in ⩾5% of DLBCL, FL or BL.
|
26473533 |
2015 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recurrent somatic heterozygous gain-of-function mutations of EZH2 have been identified in DLBCL, most notably affecting tyrosine 641 (Y641), inducing hyper-trimethylation of H3K27 (H3K27me3).
|
25762637 |
2015 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Gain-of-function mutations of enhancer of Zeste homolog 2 (EZH2) occur frequently in diffuse large B-cell lymphomas and in follicular lymphomas.
|
24634383 |
2014 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Prioritized alterations in epigenetic modulators were common and included gain-of-function EZH2 and loss-of-function ARID1A mutations (14% of diffuse large B-cell lymphomas and 22% of follicular lymphomas contained alterations in each of these two genes).
|
27102345 |
2016 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.
|
20081860 |
2010 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In particular, recurrent gain-of-function mutations targeting EZH2 Y641 occur most frequently in follicular lymphoma and aggressive diffuse large B-cell lymphoma and are associated with H3K27me3 hyperactivation, which contributes to lymphoma pathogenesis.
|
24469040 |
2015 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Activating mutations of genes involved in the BCR and NF-κB pathways (CD79A, CD79B, MYD88, and CARD11) or in epigenetic regulation (EZH2) have been recently reported, preferentially in one of the two DLBCL subtypes.
|
24327543 |
2014 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study, we treated Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) cell lines with 3-deazaneplanocin-A (DZNep), an indirect EZH2 inhibitor which possesses anticancer properties both in-vitro and in-vivo.
|
31419226 |
2019 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mutations in EZH2 (Y646) and CD79B (Y196) were detected in 13.2% and 8% of the samples, respectively, almost exclusively in follicular lymphomas and diffuse large B-cell lymphomas.
|
23361872 |
2013 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
GSK126 effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice.
|
23051747 |
2012 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In conclusion, H3K27me3 was related to EZH2 and c-Myc expression, suggesting formation of a MYC-EZH2-H3K27me3 loop in a subgroup of DLBCL cases.
|
25149548 |
2014 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL.
|
28835384 |
2017 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Moreover, oncogenic BCL6 and EZH2 cooperate to accelerate diffuse large B cell lymphoma (DLBCL) development and combinatorial targeting of these repressors results in enhanced anti-lymphoma activity in DLBCLs.
|
27505670 |
2016 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the potential signaling molecules that regulate EZH2 overexpression in aggressive B-cell lymphomas and found that 80% of cases of EZH2-positive diffuse large B-cell lymphoma show high p-ERK1/2 expression (average ~57% tumor cell positivity).
|
27282353 |
2016 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
Biomarker
|
disease |
CTD_human |
These mutations, which result in the replacement of a single tyrosine in the SET domain of the EZH2 protein (Tyr641), occur in 21.7% of GCB DLBCLs and 7.2% of FLs and are absent from ABC DLBCLs.
|
20081860 |
2010 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
High-level EZH2 and H3K27me3 were common in DLBCL independent of cell-of-origin and EZH2 mutation.
|
25651430 |
2015 |
Diffuse Large B-Cell Lymphoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that DLBCL was associated with increased expression of the EZH2 PcG protein and Ki67.
|
24304372 |
2014 |