F2, coagulation factor II, thrombin, 2147

N. diseases: 490; N. variants: 42
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE In this review we focus on available evidence and controversies regarding the relationship between the classic inherited VTE risk factors (factor V Leiden, prothrombin 20210A, deficiencies of antithrombin, protein C, and protein S) and the risk of myocardial infarction (MI). 31025650 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE Conversely, the prevalence of prothrombin mutation did not differ between patients with MI and controls. 29054763 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE Moreover, prothrombin G20210A polymorphism increases MI risk in an age-related manner. 29051591 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE In this study, we proposed to determine the prevalence of 20210A prothrombin variant among Tunisian population, and to evaluate the potential relevance of this variant with myocardial infarction. 27306359 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE Smoking (OR, 2.48; 95 % CI, 1.20-5.15), the A1691 mutation in factor V gene (OR, 3.64; 95 % CI, 1.31-10.10), and the A20210 mutation in the prothrombin gene (OR, 8.40; 95 % CI 3.35-21.05) were associated with FH of premature stroke (n = 33), while circulating anti-phospholipids to FH of premature myocardial infarction (n = 45; OR, 3.48; 95 % CI, 1.61-7.51). 25413729 2015
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE Our results indicate that neither factor V Leiden nor the prothrombin G20210A contributed to the risk factors for myocardial infarction. 22483732 2013
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE In case-control studies, multifactorially adjusted odds ratios for Prothrombin G20210A heterozygotes versus non-carriers were 2.0(1.1-3.4) for IHD, 2.0(1.0-3.8) for MI, 1.4(0.7-3.1) for ICVD, and 2.1(0.8-5.4) for IS. 19524925 2010
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE Myocardial infarction in a young patient with a previous history of repeated thrombophlebitis: combination of factor V Leiden and prothrombin G20210A gene polymorphisms with coronary artery disease. 19829138 2010
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE We studied 609 patients with venous thromboembolism (287 with factor V Leiden, and 322 with prothrombin 20210A), 174 patients with myocardial infarction (78 with factor V Leiden, and 96 with prothrombin 20210A), and 198 controls (96 with factor V Leiden, and 102 with prothrombin 20210A). 18387978 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE We report a case of myocardial infarction at a young age in a subject heterozygous for the G20210A prothrombin gene variant and homozygous for the C677T MTHFR polymorphism, who presented a strong family history of atherothrombosis. 17920139 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease LHGDN Acute myocardial infarction following an arthropod bite: is hereditary thrombophilia a contributing factor? 16988555 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE These preliminary results suggest that common genetic variants in the prothrombin gene or other variants in linkage disequilibrium are associated with myocardial infarction in postmenopausal women. 16467413 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease LHGDN A patient with hemophilia A is reported who had an acute myocardial infarction and in whom investigation for hereditary thrombophilia showed a prothrombotic molecular defect, the G20210A prothrombin mutation. 16015425 2005
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease LHGDN [Frequency of prothrombin gene G20210A variant in the 3'-untranslated region in Zhuang ethnic Chinese]. 15952132 2005
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE The prothrombin mutation is a mild risk factor for VTE within families of carriers but does not seem to play an important role in arterial thrombotic disease, with the exception of myocardial infarction, or in pregnancy-related complications. 15451770 2004
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE Genotyping at the 20210 prothrombin gene locus was performed in 162 patients with a first episode of myocardial infarction (MI) or unstable angina (UA) occurring before 65 years of age. 15377476 2004
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE G20210A prothrombin gene polymorphism may represent a modest but significant risk factor for myocardial infarction at young ages and favour the expression of ischaemic heart disease among individuals who have a limited extent of coronary atherosclerosis at angiography. 14676252 2004
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE Combined carrier status of prothrombin 20210A and factor XIII-A Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction. 12480694 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE We investigated the relationship between polymorphisms in the Factor V (Leiden), prothrombin (20210 GgA) and thrombomodulin (Ala455Val) genes in patients with a myocardial infarction (MI) <45 years of age (n=195) and in unaffected siblings (n=107) and unrelated healthy race-matched individuals drawn from the same community (n=300). 14523329 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE We conclude that factor V Leiden and prothrombin 20210A do not add substantially to the overall risk of myocardial infarction in young women. 12877676 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker disease BEFREE Genetic abnormalities specific to factor V, prothrombin,and homocysteine metabolism increase the risk for myocardial infarction and ischemic stroke, particularly among younger patients and women. 14660985 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE In conclusion, our data indicate that the G20210A mutation in the prothrombin gene was the only genetic prothrombotic risk factor associated with the risk of developing MI under the age of 36 years. 12888875 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE The frequency of heterozygotes for the 20210A prothrombin allele was 6.5% among patients and 2.8% among controls (OR 2.4, 95% CI 1.0-5.9), increasing to 8.7% in patients with a family history of myocardial infarction (OR 3.3, 95% CI 1.2-9.1), to 9.9% in patients (n=81) with < or =1 vessel disease (OR 3.8, 95% CI 1.3-10.8), and to 13.0% in patients who were normocholesterolaemic, non-diabetic, normotensive and non-smokers (OR 5.1, 95% CI 1.2-21.4). 11741359 2002
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE The prothrombin G20210A polymorphism in patients with myocardial infarction. 12439145 2002
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 GeneticVariation disease BEFREE The factor V Leiden and prothrombin G20201A mutations did not significantly correlate with myocardial infarction (OR 1.26, 95% CI 0.94 to 1.67, P=0.12 and OR 0.89, 95% CI 0.59 to 1.35, P=0.6, respectively). 11748101 2001