Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this review we focus on available evidence and controversies regarding the relationship between the classic inherited VTE risk factors (factor V Leiden, prothrombin 20210A, deficiencies of antithrombin, protein C, and protein S) and the risk of myocardial infarction (MI).
|
31025650 |
2019 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Conversely, the prevalence of prothrombin mutation did not differ between patients with MI and controls.
|
29054763 |
2018 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, prothrombin G20210A polymorphism increases MI risk in an age-related manner.
|
29051591 |
2017 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we proposed to determine the prevalence of 20210A prothrombin variant among Tunisian population, and to evaluate the potential relevance of this variant with myocardial infarction.
|
27306359 |
2016 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Smoking (OR, 2.48; 95 % CI, 1.20-5.15), the A1691 mutation in factor V gene (OR, 3.64; 95 % CI, 1.31-10.10), and the A20210 mutation in the prothrombin gene (OR, 8.40; 95 % CI 3.35-21.05) were associated with FH of premature stroke (n = 33), while circulating anti-phospholipids to FH of premature myocardial infarction (n = 45; OR, 3.48; 95 % CI, 1.61-7.51).
|
25413729 |
2015 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that neither factor V Leiden nor the prothrombin G20210A contributed to the risk factors for myocardial infarction.
|
22483732 |
2013 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In case-control studies, multifactorially adjusted odds ratios for Prothrombin G20210A heterozygotes versus non-carriers were 2.0(1.1-3.4) for IHD, 2.0(1.0-3.8) for MI, 1.4(0.7-3.1) for ICVD, and 2.1(0.8-5.4) for IS.
|
19524925 |
2010 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Myocardial infarction in a young patient with a previous history of repeated thrombophlebitis: combination of factor V Leiden and prothrombin G20210A gene polymorphisms with coronary artery disease.
|
19829138 |
2010 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied 609 patients with venous thromboembolism (287 with factor V Leiden, and 322 with prothrombin 20210A), 174 patients with myocardial infarction (78 with factor V Leiden, and 96 with prothrombin 20210A), and 198 controls (96 with factor V Leiden, and 102 with prothrombin 20210A).
|
18387978 |
2008 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report a case of myocardial infarction at a young age in a subject heterozygous for the G20210A prothrombin gene variant and homozygous for the C677T MTHFR polymorphism, who presented a strong family history of atherothrombosis.
|
17920139 |
2008 |
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
LHGDN |
Acute myocardial infarction following an arthropod bite: is hereditary thrombophilia a contributing factor?
|
16988555 |
2006 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These preliminary results suggest that common genetic variants in the prothrombin gene or other variants in linkage disequilibrium are associated with myocardial infarction in postmenopausal women.
|
16467413 |
2006 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
A patient with hemophilia A is reported who had an acute myocardial infarction and in whom investigation for hereditary thrombophilia showed a prothrombotic molecular defect, the G20210A prothrombin mutation.
|
16015425 |
2005 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
[Frequency of prothrombin gene G20210A variant in the 3'-untranslated region in Zhuang ethnic Chinese].
|
15952132 |
2005 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The prothrombin mutation is a mild risk factor for VTE within families of carriers but does not seem to play an important role in arterial thrombotic disease, with the exception of myocardial infarction, or in pregnancy-related complications.
|
15451770 |
2004 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genotyping at the 20210 prothrombin gene locus was performed in 162 patients with a first episode of myocardial infarction (MI) or unstable angina (UA) occurring before 65 years of age.
|
15377476 |
2004 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
G20210A prothrombin gene polymorphism may represent a modest but significant risk factor for myocardial infarction at young ages and favour the expression of ischaemic heart disease among individuals who have a limited extent of coronary atherosclerosis at angiography.
|
14676252 |
2004 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Combined carrier status of prothrombin 20210A and factor XIII-A Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction.
|
12480694 |
2003 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relationship between polymorphisms in the Factor V (Leiden), prothrombin (20210 GgA) and thrombomodulin (Ala455Val) genes in patients with a myocardial infarction (MI) <45 years of age (n=195) and in unaffected siblings (n=107) and unrelated healthy race-matched individuals drawn from the same community (n=300).
|
14523329 |
2003 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that factor V Leiden and prothrombin 20210A do not add substantially to the overall risk of myocardial infarction in young women.
|
12877676 |
2003 |
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic abnormalities specific to factor V, prothrombin,and homocysteine metabolism increase the risk for myocardial infarction and ischemic stroke, particularly among younger patients and women.
|
14660985 |
2003 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data indicate that the G20210A mutation in the prothrombin gene was the only genetic prothrombotic risk factor associated with the risk of developing MI under the age of 36 years.
|
12888875 |
2003 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequency of heterozygotes for the 20210A prothrombin allele was 6.5% among patients and 2.8% among controls (OR 2.4, 95% CI 1.0-5.9), increasing to 8.7% in patients with a family history of myocardial infarction (OR 3.3, 95% CI 1.2-9.1), to 9.9% in patients (n=81) with < or =1 vessel disease (OR 3.8, 95% CI 1.3-10.8), and to 13.0% in patients who were normocholesterolaemic, non-diabetic, normotensive and non-smokers (OR 5.1, 95% CI 1.2-21.4).
|
11741359 |
2002 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The prothrombin G20210A polymorphism in patients with myocardial infarction.
|
12439145 |
2002 |
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The factor V Leiden and prothrombin G20201A mutations did not significantly correlate with myocardial infarction (OR 1.26, 95% CI 0.94 to 1.67, P=0.12 and OR 0.89, 95% CI 0.59 to 1.35, P=0.6, respectively).
|
11748101 |
2001 |