F2, coagulation factor II, thrombin, 2147

N. diseases: 490; N. variants: 42
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 Biomarker phenotype RGD Hematological and morphological investigation of thrombogenic mechanisms in the lungs of phenylhydrazine-treated rats. 22402172 2013
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 Biomarker phenotype LHGDN However, a prothrombin 20210 defect should be considered in the differential diagnosis of patients with unexplained thrombosis. 17342369 2007
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 Biomarker phenotype CTD_human Cerebral venous sinus thrombosis as a recurrent thrombotic event in a patient with heterozygous prothrombin G20210A genotype after discontinuation of oral anticoagulation therapy: how long should we treat these patients with warfarin? 17245631 2007
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 Therapeutic phenotype RGD Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo. 17293494 2007
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 Biomarker phenotype LHGDN Molecular analysis of factor V Leiden, factor V Hong Kong, factor II G20210A, methylenetetrahydrofolate reductase C677T, and A1298C mutations related to Turkish thrombosis patients. 17911197 2007
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 GeneticVariation phenotype LHGDN The results indicate that FV Leiden prevalence is quite high and coexistence of FV Leiden with other hereditary causes of thrombosis such as prothrombin G20210A mutation and MTHFR enzyme defect is not rare in healthy population of Aegean region of Turkey. 17456626 2007
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 GeneticVariation phenotype LHGDN A 10-year-old boy with basilar artery thrombosis who was heterozygous for prothrombin G20210A mutation is described. 17621506 2007
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 GeneticVariation phenotype LHGDN Prothrombin G20210A gene variant is not associated with idiopathic portal vein thrombosis in an area endemic for portal vein thrombosis. 16283309 2006
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 GeneticVariation phenotype LHGDN Group 1: A total of 377 children with thrombosis were analyzed during 7 years between January 1997 and 2004 and screened for prothrombin G20210A mutation. 16020118 2005
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 GeneticVariation phenotype LHGDN The G20210A prothrombin gene, factor V Leiden, and MTHFR C677T mutations have been identified as predisposing genetic factors for thrombosis. 15958894 2005
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 GeneticVariation phenotype LHGDN A single-base change (G to A) at position 20210 in the 3' untranslated region of the prothrombin gene is associated with increased plasma levels of prothrombin and might therefore increase the risk for thrombosis. 12865818 2003
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 Biomarker phenotype CTD_human Deep vein thrombosis during enoxaparin prophylactic treatment in a young pregnant woman homozygous for factor V Leiden and heterozygous for the G127-->a mutation in the thrombomodulin gene. 11132655 2000
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 Biomarker phenotype CTD_human Pharmacological effects of a novel recombinant hirudin, CX-397, in vivo and in vitro: comparison with recombinant hirudin variant-1, heparin, and argatroban. 10064001 1999
CUI: C0040053
Disease: Thrombosis
Thrombosis
0.580 Biomarker phenotype CTD_human Effect of sodium pentosan polysulphate on the thrombogenicity of prothrombin complex concentrates. 1279834 1992