|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This may explain the greater vulnerability for addiction and obesity in individuals with C385A genetic variant and by extension, suggest that a D3 antagonism strategy in substance use disorders should consider FAAH C385A polymorphism.
|
31775159 |
2020 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to investigate the FAAH gene polymorphisms and to compare the obesity indices between different genotypes in Iranian overweight/obese women.
|
31286394 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The FAAH SNP rs324420 was associated with increased obesity (three studies).
|
30129173 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, the present study demonstrates that high fat diet intake potentiates CPS mediated inhibition of both carboxylesterase and fatty acid amide hydrolase in the liver of obese animals following subacute exposure and suggests obesity may be a risk factor for increased non-cholinergic hepatic CPS toxicity.
|
29935250 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We first report loss-of-function mutations in DGAT2 and FAAH in one obese subject, which may interact with each other to affect the adiposity penetrance, providing a model of genetic interaction associated with human obesity.
|
28243972 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the relationship of the polymorphism (cDNA 385 C->A) of FAAH gene and insulin resistance in obese patients with and without metabolic syndrome.
|
22609216 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Human FAAH gene mutations are associated with increased body weight and obesity.
|
22442717 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
The Pro129THr, C385A, polymorphism of FAAH gene (rs324420C>A) has been associated with overweight and obesity.
|
20716455 |
2011 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It has been demonstrated that the polymorphism 385 C/A of fatty acid amide hydrolase was associated with obesity.
|
20102775 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the relationship of polymorphism (cDNA 385 C-->A) of FAAH gene on obesity parameters in patients with diabetes mellitus type 2.
|
20056290 |
2010 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The set of rare variants in the FAAH promoter associated with BMI is also associated with increased level of FAAH substrate anandamide, further implicating a functional role in obesity.
|
21118518 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although analyses of these variants in 235 independent obesity families did not result in statistically significant effects (two-sided p-values between 0.14 and 0.75), the combined analysis of all 603 obesity families supported the idea of an association of two SNPs in FAAH (rs324420 and rs2295632) with early onset extreme obesity (p-values between 0.02 and 0.03).
|
20044928 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent.
|
19958092 |
2009 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
A common single nucleotide polymorphism (C385A) in the human FAAH gene has been associated with increased risk for addiction and obesity.
|
19103437 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the contribution of the FAAH gene variation in polygenic obesity and type 2 diabetes mellitus (T2DM) in the French population, we investigated the entire FAAH locus.
|
20054193 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An association between Pro129Thr variant of the FAAH gene and obesity has been described, but various studies have yielded conflicting results.
|
18819056 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study confirms previously published significant over-representations of the FAAH 385 A allele in overweight/obese subjects and presents new data in BED patients that the 385 mutation is not significantly associated with BED-related obesity.
|
18295974 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
For example, most data show decreased fatty acid amide hydrolase (FAAH) expression and/or activity as a result of obesity or high-fat intake, but the endocannabinoid predominantly increased in tissues is 2-arachidonoylglycerol (2-AG), which is not degraded by FAAH in vivo.
|
18426509 |
2008 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Following hyperinsulinemia, the FAAH mRNA levels significantly increased approximately 2-fold in the L (p=0.01 vs baseline) but not in the OB.
|
17923791 |
2007 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest a role for the FAAH 385 A/A missense polymorphism as an endocannabinoid risk factor in overweight/obesity and may provide indirect evidence to support cannabinoid antagonist treatment strategies in overweight disorders.
|
15809662 |
2005 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We measured circulating endocannabinoid concentrations and studied the expression of CB-1 and the main degrading enzyme, fatty acid amide hydrolase (FAAH), in adipose tissue of lean (n = 20) and obese (n = 20) women and after a 5% weight loss in a second group of women (n = 17).
|
16186383 |
2005 |
|
Marijuana Abuse
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We investigated a potential interaction between genetically inherited variation in fatty acid amide hydrolase (FAAH, C385A), which metabolizes the cannabis-like endocannabinoid anandamide, and dopaminergic system, measured by dopamine receptor levels and mRNA.
|
31775159 |
2020 |
|
Marijuana Abuse
|
0.380 |
Biomarker
|
disease |
BEFREE |
<i>Background</i>: Polymorphisms in cannabinoid receptor type 1 (encoded by <i>CNR1</i>) and fatty acid amide hydrolase (encoded by <i>FAAH</i>) have been associated with cannabis dependence, but it remains unknown whether variation within these genes influences cannabis' acute effects on affect.
|
31184938 |
2019 |
|
Marijuana Abuse
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Cannabis group ∗ FAAH genotype interaction predicted WM integrity in bilateral ATR (FA, right: p = .05 and left: p = .001) and fMinor (FA, p = .02).
|
26106535 |
2015 |
|
Marijuana Abuse
|
0.380 |
Biomarker
|
disease |
PSYGENET |
These findings support an association with CNR1 and FAAH genes and marijuana-related problems among regular marijuana users.
|
24172113 |
2013 |