FABP4, fatty acid binding protein 4, 2167

N. diseases: 194; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 Biomarker disease BEFREE Adipocyte fatty acid-binding protein (FABP4) played critical roles in metabolic syndrome, inflammatory responses and cardiovascular diseases. 30969942 2019
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 Biomarker disease BEFREE Fatty acid-binding protein-4 (FABP4) is an adipokine associated with obesity and signs of the metabolic syndrome. 31025416 2019
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 AlteredExpression disease BEFREE Circulating FABP4 levels are associated with several aspects of metabolic syndrome and cardiovascular disease. 30726793 2019
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 AlteredExpression disease BEFREE In this study, we demonstrate the specific overexpression of FABP4 in human HCC samples from patients with MS compared to other risk factors for chronic liver disease with FABP4 expression restricted to peritumoral endothelial cells. 30575815 2019
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 AlteredExpression disease BEFREE CTBP1 and MeS modulated the expression of multiple genes (ITGB4, ITGB6, PRSS2, COL17A1 and FABP4) and miRNAs (miR-378a-3p, miR-146a-5p, let-7e-3p, miR-381-5p, miR-194-5p, miR-494-3p) involved in BrCa progression of MDA-MB-231-derived xenografts. 29568399 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 AlteredExpression disease BEFREE Higher plasma AFABP levels are associated with increased risk of metabolic syndrome and cardiovascular morbidity in adults. 28324040 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 Biomarker disease BEFREE High serum adipocyte fatty acid binding protein level as a potential biomarker of aortic arterial stiffness in hypertensive patients with metabolic syndrome. 28860092 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 AlteredExpression disease BEFREE After adjustment for age, sex, change in percent body fat and baseline values for other metabolic and inflammatory parameters, FABP4 levels at baseline were shown to be strongly associated with the development of MetS by year 4 (odds ratio (OR), 5.75; 95% confidence interval (CI), 2.71-12.23 for highest tertile vs. lowest tertile, P<0.001) 21186114 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 Biomarker disease BEFREE All three biomarkers exhibited sexual dimorphisms (levels higher in women for fetuin-A and FABP4 but greater in men for RBP4) and were associated positively with insulin resistance assessed using the homeostasis model, with high-sensitivity C-reactive protein, and with prevalent MetSyn (P<0.01 for all). 22855337 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 Biomarker disease BEFREE Our results indicate that serum FABP4 is associated with inflammatory factors related to obesity and MS in non-diabetic morbidly obese women. 21257725 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 Biomarker disease BEFREE Role of adiponectin and adipocyte fatty acid binding protein in the metabolic syndrome. 17481768 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.100 Biomarker disease BEFREE Adipose tissue FABP (FABP4) has been suggested to be a bridge between inflammation and other pathways related to the metabolic syndrome. 17425064 2007