|
Kidney Failure, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed that the Malondialdehyde (MDA) level was increased in dose-dependent manner similar to Acsl4 gene over expression suggesting a main role of ferroptosis in hemoglobinuria mediated AKI following envenomation.
|
30890325 |
2019 |
|
Septicemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, available clinical data indicate that levels of ACSL1 and ACSL4 induction was significantly higher in fatal cases of sepsis.
|
31681299 |
2019 |
|
Gastrointestinal tract vascular insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion.
|
30737476 |
2019 |
|
Sepsis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, available clinical data indicate that levels of ACSL1 and ACSL4 induction was significantly higher in fatal cases of sepsis.
|
31681299 |
2019 |
|
Vascular insufficiency of intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion.
|
30737476 |
2019 |
|
leiomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, immunohistochemical screening of multiple soft tissue tumour arrays revealed that ACSL3 and ACSL4 were highly, but differentially, expressed in a subset of leiomyosarcomas, fibrosarcomas and rhabdomyosarcomas, with consistent cytoplasmic and granular stainings of tumour cells.
|
29450800 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Particularly, the functional integrity of ABCD2 may play an important role in OA pathogenesis via the accumulation of VLCFAs and stimulation of apoptotic death through altering profiles of miRNAs that target ACSL4.
|
30264402 |
2018 |
|
Sarcoma
|
0.010 |
Biomarker
|
group |
BEFREE |
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
|
29450800 |
2018 |
|
Nonalcoholic Steatohepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Pathologically, lowered methylation level (β-values <3.26) of ACSL4 (cg15536552) conferred susceptibility to nonalcoholic steatohepatitis (NASH).
|
29568887 |
2018 |
|
Fatty Liver Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Pathologically, lowered methylation level (β-values <3.26) of ACSL4 (cg15536552) conferred susceptibility to nonalcoholic steatohepatitis (NASH).
|
29568887 |
2018 |
|
Malignant neoplasm of soft tissue
|
0.010 |
Biomarker
|
group |
BEFREE |
The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.
|
29450800 |
2018 |
|
Basal-Like Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, ACSL4 was preferentially expressed in a panel of basal-like breast cancer cell lines and predicted their sensitivity to ferroptosis.
|
27842070 |
2017 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The ACSL4 expression in GC samples was evaluated by real-time PCR and immunohistochemistry.
|
26949059 |
2016 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of ACSL4 predicted a worse prognosis in colorectal cancer, but predicted better prognosis in breast, brain and lung cancer.
|
27171439 |
2016 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of ACSL4 predicted a worse prognosis in colorectal cancer, but predicted better prognosis in breast, brain and lung cancer.
|
27171439 |
2016 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The ACSL4 expression in GC samples was evaluated by real-time PCR and immunohistochemistry.
|
26949059 |
2016 |
|
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of ACSL4 predicted a worse prognosis in colorectal cancer, but predicted better prognosis in breast, brain and lung cancer.
|
27171439 |
2016 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of ACSL4 predicted a worse prognosis in colorectal cancer, but predicted better prognosis in breast, brain and lung cancer.
|
27171439 |
2016 |
|
Hypercholesterolemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we utilized hamsters fed a normal chow diet, a high-fat diet or a high cholesterol and high fat diet (HCHFD) as animal models to explore novel transcriptional regulatory mechanisms for ACSL4 expression under hyperlipidemic conditions.
|
25645621 |
2015 |
|
Autistic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also analyzed ACSL4 and DLG3, which have previously been known to cause XLMR and IL1RAPL2, a homologous gene for IL1RAPL1 that is mutated in autism and XLMR.
|
21384559 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that patients with SLE had higher ACSL5 transcript levels than healthy controls [median (range), healthy controls = 16.5 (12.3-18.0) vs. SLE = 26.5 (17.8-41.7), P = 3.9×10 E-5] but no differences were found for ACSL2 and ACSL4.
|
22163040 |
2011 |
|
Speech Delay
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also compared the clinical features of the family with three previously reported families with the ACSL4 gene deletion and found that ID with absent or severely delayed speech, midface hypoplasia, and facial hypotonia are consistent features observed in the absence of ACSL4 gene.
|
20186809 |
2010 |
|
Mental disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp/BMP production and visual wiring in the brain.
|
19617635 |
2009 |
|
Metabolic Syndrome X
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study shows that the common SNP (C to T substitution) in the first intron of the FACL4 gene is associated with altered FA composition of plasma phosphatidylcholines in patients with MetS.
|
19346733 |
2009 |
|
Congenital chromosomal disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The three X chromosome aberrations in the patient include: a pericentric inversion (inv 1) that disrupted the Duchenne muscular dystrophy (DMD) gene, dystrophin, at Xp11.4; an Xq11.2q21.32 approximately q22.2 paracentric inversion (inv 2) putatively affecting no genes; and an interstitial deletion at Xq22.3 that results in functional nullisomy of several known genes, including a gene previously associated with X-linked nonsyndromic mental retardation, acyl-CoA synthetase long chain family member 4 (ACSL4).
|
16276108 |
2006 |