Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1845672
Disease: Mental Retardation, X-Linked 63
Mental Retardation, X-Linked 63
0.710 GeneticVariation disease BEFREE A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients. 12525535 2003
CUI: C1845672
Disease: Mental Retardation, X-Linked 63
Mental Retardation, X-Linked 63
0.710 Biomarker disease GENOMICS_ENGLAND FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. 11889465 2002
CUI: C1845672
Disease: Mental Retardation, X-Linked 63
Mental Retardation, X-Linked 63
0.710 GeneticVariation disease UNIPROT FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. 11889465 2002
CUI: C1845672
Disease: Mental Retardation, X-Linked 63
Mental Retardation, X-Linked 63
0.710 Biomarker disease GENOMICS_ENGLAND
CUI: C1845672
Disease: Mental Retardation, X-Linked 63
Mental Retardation, X-Linked 63
0.710 Biomarker disease CTD_human
CUI: C1845672
Disease: Mental Retardation, X-Linked 63
Mental Retardation, X-Linked 63
0.710 CausalMutation disease CLINVAR
Alport Syndrome, Mental Retardation, Midface Hypoplasia, and Elliptocytosis
0.510 Biomarker disease GENOMICS_ENGLAND FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. 11889465 2002
Alport Syndrome, Mental Retardation, Midface Hypoplasia, and Elliptocytosis
0.510 Biomarker disease BEFREE Identification and characterization of mouse orthologs of the AMMECR1 and FACL4 genes deleted in AMME syndrome: orthology of Xq22.3 and MmuXF1-F3. 10828604 2000
Alport Syndrome, Mental Retardation, Midface Hypoplasia, and Elliptocytosis
0.510 ChromosomalRearrangement disease ORPHANET Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis: a new X linked contiguous gene deletion syndrome? 9598718 1998
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.360 AlteredExpression disease BEFREE Then, immunohistochemical results demonstrated that the ACSL4 positive expression rate was 70.7% in HCC tissues. 28887439 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.360 AlteredExpression disease BEFREE Interestingly, we showed that the expression levels of acyl-CoA synthetase long-chain family member 4 (ACSL4) were negatively associated with those of miR-205 in clinical HCC tissues. 24576478 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.360 Biomarker disease BEFREE The acyl-CoA synthetase 4 (ACSL4) is increased in breast cancer, colon and hepatocellular carcinoma. 21085606 2010
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.360 Biomarker disease CTD_human Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression. 19363144 2009
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.360 AlteredExpression disease BEFREE In this study, we detected the expression of FACL4 mRNA in 40 patients with hepatic carcinoma and its adjacent normal tissues by semi-quantitative RT-PCR. 18059177 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.360 Biomarker disease LHGDN FACL4 is involved in the HCC tumorigenesis and both cAMP and p38 MAPK pathways are associated with the regulation of FACL4 in HCC. 15849811 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.360 Biomarker disease BEFREE FACL4 is involved in the HCC tumorigenesis and both cAMP and p38 MAPK pathways are associated with the regulation of FACL4 in HCC. 15849811 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.360 AlteredExpression disease BEFREE We found that 14 out of 37 (37.8%) HCC expressed moderate to strong FACL4 immunostaining. 12824887 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.360 AlteredExpression disease LHGDN We found that 14 out of 37 (37.8%) HCC expressed moderate to strong FACL4 immunostaining. 12824887 2003
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 AlteredExpression disease BEFREE Despite ACSL4 expression is upregulated progressively in CRC-like organoids, metformin is able to downregulate its expression, especially in the first two stages (I, II). 31339921 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 AlteredExpression disease BEFREE Here, we focus on functional differences and individual contribution of acyl coA synthetases (ACSL) isoforms to the previously described ACSL/stearoyl-CoA desaturase (ACSL1/ACSL4/SCD) metabolic network causing invasion and poor prognosis in colorectal cancer (CRC). 28894242 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 AlteredExpression disease BEFREE High expression of ACSL4 predicted a worse prognosis in colorectal cancer, but predicted better prognosis in breast, brain and lung cancer. 27171439 2016
CUI: C2931498
Disease: Mental Retardation, X-Linked 1
Mental Retardation, X-Linked 1
0.330 AlteredExpression disease BEFREE Interestingly, expression of an MRX-associated ACSL4 mutant form in a wild-type background led to the lesions in visual center, suggesting a dominant negative effect. 19617635 2009
CUI: C2931498
Disease: Mental Retardation, X-Linked 1
Mental Retardation, X-Linked 1
0.330 Biomarker disease BEFREE As skewed X-inactivation, an apparently constant feature in FACL4 carrier females was not observed in an obligate carrier belonging to the MRX family presented here, the PAK3 gene should be considered as the strongest candidate for this MRX locus. 12949969 2003
CUI: C2931498
Disease: Mental Retardation, X-Linked 1
Mental Retardation, X-Linked 1
0.330 GeneticVariation disease BEFREE A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients. 12525535 2003
CUI: C2931498
Disease: Mental Retardation, X-Linked 1
Mental Retardation, X-Linked 1
0.330 GermlineCausalMutation disease ORPHANET FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. 11889465 2002