|
Carotid Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Common carotid artery intima-media thickness (CCA-IMT), carotid plaques and carotid stenosis were measured at both common carotid arteries using an edge detection system.
|
30909115 |
2020 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study aimed to investigate the clinicopathological and radiological features of cHCC-CCA and compare their outcomes with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).
|
30876788 |
2020 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, LINC00261 could be a promising biomarker and therapeutic target for CCA, and in the high level of LINC00261 in CCA, E-cadherin or CDH1 might be an effective factor for tumor metastasis or poor prognosis.
|
31812439 |
2020 |
|
Congenital chromosomal disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Most of the patients with CCA/Ph- cells demonstrated no significant dysplasia or increased blasts with two exceptions: one patient with persistent 7q- exhibiting mild dysmegakaryopoiesis, suggestive of an early evolving myelodysplastic syndrome, and another patient with complex cytogenetic abnormalities who developed acute myeloid leukemia after gained MLL amplification.
|
31425925 |
2019 |
|
Eclampsia
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study examined whether individual CCA wall layers, risk factors for cardiovascular disease, and markers of endothelial dysfunction had normalized or remained unfavorable seven years after pre-eclampsia.
|
31200939 |
2019 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
<b>Abbreviations</b> PSC: Primary sclerosing cholangitis; IBD: inflammatory bowel disease; CCA: cholangiocarcinoma; SAP: serum alkaline phosphatase; ULN: upper limit of normal; UDCA: ursodeoxycholic acid; CRP: c-reactive protein; AST: aspartate aminotransferase; ALT: alanine aminotransferase; INR: international normalized ratio; FIS: fatigue impact scale; AE: adverse events; PREsTo: PSC risk estimate tool; IQR: interquartile range; ELF: enhanced liver fibrosis.
|
31131678 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, when stratified by post-operative AKI and cell cycle arrest (CCA) biomarkers, AKI patients displayed a significant decrease in RFR {from 14.4 [interquartile range (IQR) 9.5 - 24.3] to 9.1 (IQR 7.1 - 12.5) mL/min/1.73 m2; P < 0.001} and patients without AKI but with positive post-operative CCA biomarkers also experienced a similar decrease of RFR [from 26.7 (IQR 22.9 - 31.5) to 19.7 (IQR 15.8 - 22.8) mL/min/1.73 m2; P < 0.001].
|
30053231 |
2019 |
|
Prolapsed lumbar disc
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The Student t test was used to compare the expression of FBN1 and FBN2 between patients with AIS and LDH.
|
30044367 |
2019 |
|
Endothelial dysfunction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This study examined whether individual CCA wall layers, risk factors for cardiovascular disease, and markers of endothelial dysfunction had normalized or remained unfavorable seven years after pre-eclampsia.
|
31200939 |
2019 |
|
Recurrent Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
When M and L tumor burdens did not exceed Milan (class B or A), rHCC was low (≤10%) as in AAA, ABA, ABB, BBA, BBB; rHCC was also low (≤10%) with successful downstaging when L was A (<Milan) and M tumor burden did not exceed I, as in BBA, CCA, and DDA.
|
30706653 |
2019 |
|
Tracheomalacia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analysis of human tracheal tissues indicates that a decrease in ECM proteins, including FBN2 and Fibronectin, is associated with tracheomalacia.Our findings provide novel insights into the role of ECM homeostasis in mesenchymal cell polarisation during tracheal tubulogenesis.
|
30578393 |
2019 |
|
Vegetation
|
0.010 |
Biomarker
|
disease |
BEFREE |
The application of TWINSPAN, DCA and CCA multivariate analyses led to identify 3 vegetation groups (VGI: <i>Pulicaria undulata</i>-<i>Prunus arabica,</i> VGII: <i>Prunus arabica-Artemisia seiberi</i>, VGIII: <i>Artemisia seiberi-Achillea fragrantissima</i>) associated with the distribution of <i>P. arabica</i>.
|
31485172 |
2019 |
|
Cholangiolocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined genetic alterations of hTERT promoter (hTERT), IDH1 or 2 (IDH1/2), KRAS, ARID1A, PBRM1, ARID2, BAP1, p53 and their association with histologic features such as proportion of CLC and DPM-pattern in 77 patients with primary liver carcinoma diagnosed as cHCC-CCA or CLC.
|
30520820 |
2019 |
|
Congenital Abnormality
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We report a 29 week fetus with arthrogryposis multiplex congenita, multiple joint dislocations, scoliosis and dysmorphism who was detected to be double heterozygote for putatively pathogenic FBN1 (NM_000138.4:c.6004C > T; p.Pro2002Ser) and FBN2 (NM_001999.3:c.2945G > T; p.Cys982Phe) variants on exome sequencing.
|
29501612 |
2018 |
|
Metabolic Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Areas of intense research include their multifaceted roles in metabolic diseases (non-alcoholic steatohepatitis, NASH), fibrosis or liver cancer (hepatocellular or cholangiocellular carcinoma, HCC or CCA).
|
29454647 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated the presence of autoantibodies against the extracellular matrix proteins thrombospondin-4 (TSP-4), cartilage oligomeric matrix protein (COMP), C-type lectin domain family 3 member A (CLEC3A), collagen II, collagen VI, matrilin-3, and fibrillin-2 in the serum of osteoarthritis (OA) patients.
|
30001809 |
2018 |
|
Retinitis Pigmentosa
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the human TRNT1 gene encoding tRNA nucleotidyltransferase (tRNA-NT), an essential enzyme responsible for addition of the CCA (cytidine-cytidine-adenosine) sequence to the 3'-termini of tRNAs, have been linked to disease phenotypes including congenital sideroblastic anemia with B-cell immunodeficiency, periodic fevers and developmental delay (SIFD) or retinitis pigmentosa with erythrocyte microcytosis.
|
29454993 |
2018 |
|
Schistosomiasis mansoni
|
0.010 |
Biomarker
|
disease |
BEFREE |
Results showed POC-CCA technique as an effective, sensitive and accurate screening tool for Schistosoma mansoni infection in areas of low prevalence.
|
29642875 |
2018 |
|
Lysosomal Storage Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
AMPK: AMP-activated protein kinase; BafA: bafilomycin A<sub>1</sub>; BNIP3L: BCL2/adenovirus E1B interacting protein 3-like; CCA: chronic contractile activity; COX4I1: cytochrome c oxidase subunit 4I1; DMEM: Dulbecco's modified Eagle's medium; GFP: green fluorescent protein; LSD: lysosomal storage diseases; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; PPARGC1A: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; PINK1: PTEN induced putative kinase 1; ROS: reactive oxygen species; SOD2: superoxide dismutase 2, mitochondrial; SQSTM1/p62: sequestosome 1; TFEB: transcription factor EB.
|
30078345 |
2018 |
|
Essential Hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the relationship between common carotid artery diameter (CCA-D) and target organ damage (TOD) in essential hypertension.
|
29035944 |
2018 |
|
Left Ventricular Hypertrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with CCA-D/height more than 3.905 mm/m have higher left ventricular mass index (LVMI) (P < 0.001) and higher prevalence of left ventricular hypertrophy (LVH) (P < 0.001), higher mean common carotid intima-media thickness (P = 0.008) and higher prevalence of carotid artery sclerosis (P = 0.03), higher pulse wave velocity (PWV) (P < 0.001) and higher prevalence of increased arterial stiffness (P = 0.01), higher urinary albumin/creatinine ratio (P = 0.001) and higher prevalence of microalbuminuria (P = 0.02) and greater number of TODs (P < 0.001) compared with the patients with CCA-D/height less than 3.905 mm/m.
|
29035944 |
2018 |
|
Hereditary sideroblastic anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the human TRNT1 gene encoding tRNA nucleotidyltransferase (tRNA-NT), an essential enzyme responsible for addition of the CCA (cytidine-cytidine-adenosine) sequence to the 3'-termini of tRNAs, have been linked to disease phenotypes including congenital sideroblastic anemia with B-cell immunodeficiency, periodic fevers and developmental delay (SIFD) or retinitis pigmentosa with erythrocyte microcytosis.
|
29454993 |
2018 |
|
Dyslipidemias
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Multivariate analysis of genomics data to identify potential pleiotropic genes for type 2 diabetes, obesity and dyslipidemia using Meta-CCA and gene-based approach.
|
30110382 |
2018 |
|
Aneurysm of femoral artery
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Femoral Artery Aneurysm Repair in a Patient With a Fibrillin-2 Mutation.
|
29742989 |
2018 |
|
Anastomosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CCA, outward remodeling of capillaries that anastomose 2 arteriolar trees with different parent feed arteries, may represent a therapeutic target for patients who lack collaterals.
|
29285816 |
2018 |