|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have showed that genetic variants in phosphatase and actin regulator 1 (PHACTR1) are associated with coronary artery disease and myocardial infarction.
|
30293016 |
2018 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Recently, certain polymorphisms in the phosphatase and actin regulator 1 (PHACTR1) gene have been shown to be associated with CVD (i.e., coronary artery disease, coronary artery calcification, early onset myocardial infarction, cervical artery dissection and hypertension) in different ethnic groups.
|
27876132 |
2016 |
|
Myocardial Infarction
|
0.490 |
Biomarker
|
disease |
BEFREE |
How these PHACTR1 SNPs influence CAD/MI risk, and whether PHACTR1 itself is the causal gene at the locus, is currently unknown.
|
25838425 |
2015 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
The rs12526453 Polymorphism in an Intron of the PHACTR1 Gene and Its Association with 5-Year Mortality of Patients with Myocardial Infarction.
|
26086777 |
2015 |
|
Myocardial Infarction
|
0.490 |
Biomarker
|
disease |
CTD_human |
In human subjects, MI associated PHACTR1 allele was not associated significantly with cardiac function (n = 1550).
|
26098115 |
2015 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
In human subjects, MI associated PHACTR1 allele was not associated significantly with cardiac function (n = 1550).
|
26098115 |
2015 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Comparisons of allele frequencies by the χ(2) test revealed that rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1, FDR=0.0007), rs4977574 of the CDKN2B antisense RNA 1 gene (CDKN2B-AS1, FDR=0.0038), rs264 of the lipoprotein lipase gene (LPL, FDR=0.0061), rs599839 of the proline/serine-rich coiled-coil 1 gene (PSRC1, FDR=0.0118), rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1, FDR=0.0118) and rs12413409 of the cyclin and CBS domain divalent metal cation transport mediator 2 gene (CNNM2, FDR=0.0300) were significantly associated with MI.
|
25738804 |
2015 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
The GWAS discovered MI risk variant at 6p24 in the protein phosphatase 1 regulator gene (PHACTR1) is associated with adverse arterial wave reflection indexes and may mediate MI risk through this pathway.
|
22513829 |
2012 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
SNPs in the 9p21 and PHACTR1 gene loci were strongly associated with CAC and MI, and there are suggestive associations with both CAC and MI of SNPs in additional loci.
|
22144573 |
2011 |
|
Myocardial Infarction
|
0.490 |
Biomarker
|
disease |
CTD_human |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
|
19198609 |
2009 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
|
19198609 |
2009 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
|
19198609 |
2009 |