|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
WT mice treated with the RAGE-specific inhibitor FPS-ZM1 experienced less severe enteritis and colitis.
|
30542111 |
2019 |
|
Enteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
WT mice treated with the RAGE-specific inhibitor FPS-ZM1 experienced less severe enteritis and colitis.
|
30542111 |
2019 |
|
Gonorrhea
|
0.010 |
Biomarker
|
disease |
BEFREE |
GC treatment induced RAGE and galectin expression in mast cells, and blocking these agents by FPS-ZM1 or GSC-100 significantly reversed mast cell numbers in the peritoneal cavity and mesenteric tissue of GC-treated mice.
|
30199117 |
2019 |
|
Leishmaniasis, Cutaneous
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, our findings have confirmed the essentiality of FPPS in both promastigotes and amastigotes in L. major and thus validate its potential as a drug target for the treatment of cutaneous leishmaniasis.
|
30926449 |
2019 |
|
Codependency
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate that FPS and other conditional phenotypes may not be well suited to serve as endophenotypes unless such codependency can be disentangled.
|
30613993 |
2019 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
While FPS-ZM1 alone had no appreciable effects on the renal fibrosis, the combination treatment ameliorated fibrosis better than valsartan in the kidneys.
|
30393200 |
2019 |
|
Anemia, Sickle Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
Psychometric Properties of a Modified Version of the Faces Pain Scale-Revised (Modified FPS-R) to Evaluate Worst Pain in Children and Adolescents With Sickle Cell Anemia.
|
30044349 |
2018 |
|
Bone Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Nitrogen-containing bisphosphonates (N-BPs) have been used widely to treat various bone diseases by inhibiting the key enzyme farnesyl pyrophosphate synthase (FPPS) in the mevalonate pathway.
|
29080272 |
2018 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
To investigate restorative effects of the receptor for advanced glycation end products (RAGE)-specific inhibitor FPS-ZM1 on abnormal amyloid β (Aβ) influx across the blood brain-barrier (BBB) and cognitive deficits in db/db mice.
|
29248482 |
2018 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multivariate analysis, controlling for age, gender, education and personal experience with the stigma condition (e.g. having obesity or depression), show that the double stigma obesity and depression is associated to more negative attitudes on the FPS (b=0.163, p<0.001) and the DS (b=0.154, p=0.002) compared to the single-stigma condition.
|
29455896 |
2018 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multivariate analysis, controlling for age, gender, education and personal experience with the stigma condition (e.g. having obesity or depression), show that the double stigma obesity and depression is associated to more negative attitudes on the FPS (b=0.163, p<0.001) and the DS (b=0.154, p=0.002) compared to the single-stigma condition.
|
29455896 |
2018 |
|
Malaria, Falciparum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key branchpoint enzyme in isoprenoid biosynthesis in Plasmodium falciparum (malaria) parasites.
|
29276048 |
2018 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we report that pitavastatin and other lipophilic statins are potent inhibitors of DSB repair in breast and melanoma models both <i>in vitro</i> and <i>in vivo</i> When combined with ionizing radiation, pitavastatin increased persistent DSBs, induced senescence, and enhanced acute effects of radiation on radioresistant melanoma tumors. shRNA knockdown implicated HMG-CoA reductase, farnesyl diphosphate synthase, and protein farnesyl transferase in IRIF resolution, DSB repair, and senescence.
|
29030460 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, FPPS expression was significantly correlated with TNM stage, and metastasis.
|
29337059 |
2018 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multivariate analysis, controlling for age, gender, education and personal experience with the stigma condition (e.g. having obesity or depression), show that the double stigma obesity and depression is associated to more negative attitudes on the FPS (b=0.163, p<0.001) and the DS (b=0.154, p=0.002) compared to the single-stigma condition.
|
29455896 |
2018 |
|
Chagas Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the increase of the anti-T. cruzi activity upon coordination could not be explained neither through the inhibition of TcFPPS nor through the inhibition of TcSPPS (T. cruzi solanesyl-diphosphate synthase).
|
29349663 |
2018 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Farnesyl pyrophosphate synthase (FPPS), a key enzyme in the mevalonate pathway, was recently shown to play a role in cancer progression.
|
29337059 |
2018 |
|
Impaired cognition
|
0.010 |
Biomarker
|
disease |
BEFREE |
Downregulation of abnormal Aβ influx across the BBB by FPS-ZM1 at higher dosage contributes to reduced neuronal apoptosis, improved hippocampal plasticity and cognitive impairment in db/db mice.
|
29248482 |
2018 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Multivariate analysis, controlling for age, gender, education and personal experience with the stigma condition (e.g. having obesity or depression), show that the double stigma obesity and depression is associated to more negative attitudes on the FPS (b=0.163, p<0.001) and the DS (b=0.154, p=0.002) compared to the single-stigma condition.
|
29455896 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
FPPS expression of FPPS was induced by TGF-β1 and FPPS promoted cell invasion and EMT via the RhoA/Rock1 pathway.
|
29337059 |
2018 |
|
Infectious Otitis Media
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In children with AOM (n = 201), pain was assessed by parents as moderate/severe in 65% via interview; 90% with the FPS-R; and 91% with the FLACC Scale (P < 0.001).
|
30572868 |
2018 |
|
Pain in children
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Psychometric Properties of a Modified Version of the Faces Pain Scale-Revised (Modified FPS-R) to Evaluate Worst Pain in Children and Adolescents With Sickle Cell Anemia.
|
30044349 |
2018 |
|
Diminished ovarian reserve
|
0.010 |
Biomarker
|
disease |
BEFREE |
AFC: antral follicle count; BMI: body mass index; DOR: diminished ovarian reserve; E2: estradiol; FPS: follicular-phase stimulation; FSH: follicle stimulating hormone; GnRH: gonadotropin-releasing hormone; HCG: human chorionic gonadotropin; IRB: institutional review board; IVF: in vitro fertilization; LH: luteinizing hormone; LPS: luteal-phase stimulation; MII: metaphase II.
|
29564925 |
2018 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
Facial Pain Scale Revised (FPS-R) and Face, Leg, Activity, Cry, Consolability (FLACC) scores were used to evaluate pain and anxiety before, during and after procedure.
|
28190665 |
2017 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Facial Pain Scale Revised (FPS-R) and Face, Leg, Activity, Cry, Consolability (FLACC) scores were used to evaluate pain and anxiety before, during and after procedure.
|
28190665 |
2017 |