|
Diabetes
|
0.070 |
Biomarker
|
disease |
BEFREE |
Rfx6 could prove useful in efforts to generate beta-cells for patients with diabetes.
|
20148032 |
2010 |
|
Diabetes Mellitus
|
0.070 |
Biomarker
|
group |
BEFREE |
Rfx6 could prove useful in efforts to generate beta-cells for patients with diabetes.
|
20148032 |
2010 |
|
Diabetes
|
0.070 |
Biomarker
|
disease |
BEFREE |
RFX6 heterozygotes have reduced penetrance of diabetes compared to common HNF1A and HNF4A-MODY mutations (27, 70 and 55% at 25 years of age, respectively).
|
29026101 |
2017 |
|
Diabetes Mellitus
|
0.070 |
Biomarker
|
group |
BEFREE |
RFX6 heterozygotes have reduced penetrance of diabetes compared to common HNF1A and HNF4A-MODY mutations (27, 70 and 55% at 25 years of age, respectively).
|
29026101 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A heterozygous protein-truncating RFX6 variant in a family with childhood-onset, pregnancy-associated and adult-onset diabetes.
|
31001871 |
2019 |
|
Prostate carcinoma
|
0.160 |
GeneticVariation
|
disease |
GWASCAT |
A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
|
26034056 |
2015 |
|
Mitchell-Riley Syndrome
|
0.750 |
GeneticVariation
|
disease |
BEFREE |
After other gene testing was negative, the clinical diagnosis of Mitchell-Riley syndrome was ultimately considered and further genetic analysis revealed a novel missense homozygous variant in RFX6: c.983A>T (p.asp328Val).
|
31275908 |
2019 |
|
melanoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation.
|
22535842 |
2012 |
|
Malignant neoplasm of prostate
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Association of THADA, FOXP4, GPRC6A/RFX6 genes and 8q24 risk alleles with prostate cancer in Northern Chinese men.
|
26537068 |
2016 |
|
Prostate carcinoma
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Association of THADA, FOXP4, GPRC6A/RFX6 genes and 8q24 risk alleles with prostate cancer in Northern Chinese men.
|
26537068 |
2016 |
|
Congenital Abnormality
|
0.010 |
Biomarker
|
group |
BEFREE |
Because of this, we propose that MFS/MRS is a symptom continuum or an RFX6 malformation complex.
|
25421130 |
2014 |
|
Deformity
|
0.010 |
Biomarker
|
group |
BEFREE |
Because of this, we propose that MFS/MRS is a symptom continuum or an RFX6 malformation complex.
|
25421130 |
2014 |
|
Martinez-Frias Syndrome
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Biallelic RFX6 mutations can cause childhood as well as neonatal onset diabetes mellitus.
|
26264437 |
2015 |
|
Anorectal Malformations
|
0.300 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Biallelic RFX6 mutations can cause childhood as well as neonatal onset diabetes mellitus.
|
26264437 |
2015 |
|
Mitchell-Riley Syndrome
|
0.750 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Biallelic truncating or mis-sense mutations in the DNA-binding domain of the RFX6 transcription factor cause an autosomal recessive, syndromic form of neonatal diabetes previously described as Mitchell-Riley syndrome.
|
26264437 |
2015 |
|
Mitchell-Riley Syndrome
|
0.750 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Biallelic truncating or mis-sense mutations in the DNA-binding domain of the RFX6 transcription factor cause an autosomal recessive, syndromic form of neonatal diabetes previously described as Mitchell-Riley syndrome.
|
26264437 |
2015 |
|
Malignant neoplasm of prostate
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Case-control analysis of allelic frequency of PCa associated with PCa showed that one of the 6 candidate risk loci, rs339331 in the RFX6 gene, was associated with reduced risk of prostate cancer (odds ratio (OR) = 0.73, 95% confidence interval (CI) =0.57-0.94, P = 0.013) in northern Chinese men.
|
23803082 |
2013 |
|
Prostate carcinoma
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Case-control analysis of allelic frequency of PCa associated with PCa showed that one of the 6 candidate risk loci, rs339331 in the RFX6 gene, was associated with reduced risk of prostate cancer (odds ratio (OR) = 0.73, 95% confidence interval (CI) =0.57-0.94, P = 0.013) in northern Chinese men.
|
23803082 |
2013 |
|
Maturity onset diabetes mellitus in young
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Clinical analysis of 36 individuals suggested that RFX6 mutation-induced MODY is characterized by low penetrance and relatively late onset.
|
31001871 |
2019 |
|
Mitchell-Riley Syndrome
|
0.750 |
GermlineCausalMutation
|
disease |
ORPHANET |
Clinical characterization of a newly described neonatal diabetes syndrome caused by RFX6 mutations.
|
21965172 |
2011 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Clinical data indicate that RFX6 upregulation in human prostate cancers correlates with tumor progression, metastasis and risk of biochemical relapse.
|
24390282 |
2014 |
|
Mitchell-Riley Syndrome
|
0.750 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population.
|
27167055 |
2016 |
|
Malabsorption Syndrome
|
0.110 |
Biomarker
|
group |
BEFREE |
Finally, we identified transcriptional changes uncovering adaptive responses to the prolonged lack of enteroendocrine hormones and leading to malabsorption and lower food efficiency ratio in Rfx6-deficient mouse intestine.
|
31668390 |
2019 |
|
Prostatic Neoplasms
|
0.310 |
GeneticVariation
|
group |
BEFREE |
Finally, we observe a significant association between the risk-associated T allele at rs339331 and increased RFX6 mRNA levels in human prostate tumors.
|
24390282 |
2014 |
|
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Finally, we observe a significant association between the risk-associated T allele at rs339331 and increased RFX6 mRNA levels in human prostate tumors.
|
24390282 |
2014 |