FGF2, fibroblast growth factor 2, 2247

N. diseases: 635; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.340 Biomarker disease BEFREE The expression levels of α-SMA, p-FGFRs, p-ERK1/2 and p-Smad3 in the lungs of sFGFR2c-treated mice were markedly lower. sFGFR2c may have potential for the treatment of lung fibrosis as an FGF-2 antagonist. 22451267 2012
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.340 AlteredExpression disease BEFREE In a mouse model of lung fibrosis, oral administration of NTS (30 mg·kg<sup>-1</sup>·d<sup>-1</sup>, for 1 or 2 weeks) effectively attenuated bleomycin-induced pulmonary fibrosis by inhibiting the levels of HIF-1α and its downstream profibrotic factors (TGF-β, FGF2 and α-SMA). 29645000 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.340 Biomarker disease BEFREE We conclude that FGF2 is not required for bleomycin-induced pulmonary fibrosis, but rather is essential for epithelial repair and maintaining epithelial integrity after bleomycin-induced lung injury in mice. 24988442 2015
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.340 AlteredExpression disease BEFREE In summary, overexpression of FGF2 protects against bleomycin-induced pulmonary fibrosis in vivo and reverses TGFβ1-induced collagen and αSMA expression and stress fiber formation in lung fibroblasts in vitro, without affecting either inflammation or epithelial gene expression. 29873400 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.340 Biomarker disease CTD_human Only one bFGF isoform (17.8 kd) was found in idiopathic pulmonary fibrosis and chronic beryllium disease lung tissues and interacted with heparin-like molecules in the lung. 8952537 1996