FGF2, fibroblast growth factor 2, 2247

N. diseases: 635; N. variants: 7
Disease: Addictive Behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.020 AlteredExpression phenotype BEFREE Patients 45 years of age or older had significantly higher plasma levels of CCL11, fibroblast growth factor 2 (FGF-2), nicotine metabolite cotinine, and a longer duration of addiction. 29222992 2018
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.020 Biomarker phenotype BEFREE Together, our results suggest that alcohol consumption increases the expression of <i>Fgf2</i> in the DMS, and that striatal FGF2 promotes alcohol consumption, suggesting that FGF2 in the DMS is a positive regulator of alcohol drinking.<b>SIGNIFICANCE STATEMENT</b> Long-term alcohol intake may lead to neuroadaptations in the mesostriatal reward system, resulting in addiction phenotypes. 28821667 2017