FGF2, fibroblast growth factor 2, 2247

N. diseases: 635; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE In addition, we found that glioblastoma exosomes contained significant amounts of the proteoglycans glypican-1 and syndecan-4, which can serve as co-receptors for angiogenic factors, including fibroblast growth factor-2 (FGF-2). 28699397 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE Acidic pH with coordinated reduction of basic fibroblast growth factor maintains the glioblastoma stem cell-like phenotype in vitro. 28063758 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE MiR-302d and miR-16 inhibit tumorigenesis by down-regulating p65 and FGF2, which potentially contributes to the treatment of glioblastoma with clinical relevance. 28497156 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE In this study, we used inhibitors to block specific signaling pathways, including JAK, PI3K/Akt, and Src pathways, to explore how bFGF mediates crosstalk with STAT3 in two glioblastoma(GBM) cell lines: U251 (mutant p53) and U87 (wild-type p53). 25048528 2014
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression disease BEFREE Adenovirus-mediated transfer of siRNA against basic fibroblast growth factor mRNA enhances the sensitivity of glioblastoma cells to chemotherapy. 20221717 2011
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE A glioblastoma stem cell (GSC) line, GSC11, grows as neurospheres in serum-free media supplemented with EGF (epidermal growth factor) and bFGF (basic fibroblast growth factor), and, if implanted in nude mice brains, will recapitulate high-grade glial tumors. 20199106 2010
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression disease BEFREE GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells. 8883950 1996
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression disease BEFREE In contrast, the glioblastoma cell line, A-172, that expressed the bFGF receptor showed a mitogenic response to bFGF but not to KGF. 8275490 1994
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 AlteredExpression disease BEFREE Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells. 8090761 1994
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.100 Biomarker disease BEFREE The specificity of the elevated transcription of TGF-alpha, TGF-beta, bFGF and flg in glioblastoma cell lines is further suggested by the fact that the transcription of the proto-oncogene c-erbB2, which is overproduced in breast tumor cell lines, was not elevated in glioblastoma cell lines. 1347915 1992