FGF5, fibroblast growth factor 5, 2250

N. diseases: 56; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.300 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C0235480
Disease: Paroxysmal atrial fibrillation
Paroxysmal atrial fibrillation 		0.300 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C4706941
Disease: Familial isolated trichomegaly
Familial isolated trichomegaly 		0.300 GermlineCausalMutation disease ORPHANET FGF5 is a crucial regulator of hair length in humans. 24989505 2014
CUI: C4083212
Disease: Alopecia, Male Pattern
Alopecia, Male Pattern 		0.110 GeneticVariation disease GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C4083212
Disease: Alopecia, Male Pattern
Alopecia, Male Pattern 		0.110 Biomarker disease BEFREE The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. 28272467 2017
CUI: C4083212
Disease: Alopecia, Male Pattern
Alopecia, Male Pattern 		0.110 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
CUI: C0002170
Disease: Alopecia
Alopecia 		0.100 GeneticVariation disease GWASCAT Genetic prediction of male pattern baldness. 28196072 2017
CUI: C0086543
Disease: Cataract
Cataract 		0.100 Biomarker disease HPO
CUI: C0162311
Disease: Androgenetic Alopecia
Androgenetic Alopecia 		0.100 GeneticVariation disease GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C0162311
Disease: Androgenetic Alopecia
Androgenetic Alopecia 		0.100 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
CUI: C2676272
Disease: Alopecia, Androgenetic, 3
Alopecia, Androgenetic, 3 		0.100 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
CUI: C2676272
Disease: Alopecia, Androgenetic, 3
Alopecia, Androgenetic, 3 		0.100 GeneticVariation disease GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C2678038
Disease: Alopecia, Androgenetic, 2
Alopecia, Androgenetic, 2 		0.100 GeneticVariation disease GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C2678038
Disease: Alopecia, Androgenetic, 2
Alopecia, Androgenetic, 2 		0.100 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
CUI: C4049090
Disease: Alopecia, Androgenetic, 1
Alopecia, Androgenetic, 1 		0.100 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
CUI: C4049090
Disease: Alopecia, Androgenetic, 1
Alopecia, Androgenetic, 1 		0.100 GeneticVariation disease GWASCAT GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. 29146897 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 Biomarker disease BEFREE We have identified the TAF/FGF5/FGFR2/c-Src/HER2 axis as an escape pathway responsible for HER2 targeted therapies resistance in breast cancer which can be reversed by FGFR inhibitors. 31699826 2020
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 Biomarker disease BEFREE CONCLUSIONS Our results suggest that FGF5 is an independent protective factor for BC patients. 29804124 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.020 GeneticVariation disease BEFREE Our findings suggest high BMI increases the effect of the blood pressure-increasing allele at rs1458038 near FGF5, further highlighting the importance of obesity prevention in reducing hypertension risk. 25618516 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.020 GeneticVariation disease BEFREE The genetic risk score (GRS), based on these three SNPs (CSK rs1378942, MTHFR rs1801133, FGF5 rs16998073), showed a positive association with risk of obesity (OR = 1.18, 95% CI 1.09-1.28, P = 7.60 × 10<sup>-5</sup>). 30217759 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.020 AlteredExpression disease BEFREE <b>Results:</b> FGF5 was significantly upregulated in OS tissues and cells, and closely associated with poor differentiation, larger tumor size, lymph node metastasis, and advanced TNM stage. 31372048 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.020 Biomarker disease BEFREE Taken together, our data indicated that miR-567 may function as a tumor suppressor by negatively regulating FGF5 and be potential therapeutic targets for the treatment of OS. 29743851 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.020 Biomarker disease BEFREE Taken together, our data indicated that miR-567 may function as a tumor suppressor by negatively regulating FGF5 and be potential therapeutic targets for the treatment of OS. 29743851 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.020 AlteredExpression disease BEFREE <b>Results:</b> FGF5 was significantly upregulated in OS tissues and cells, and closely associated with poor differentiation, larger tumor size, lymph node metastasis, and advanced TNM stage. 31372048 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 Biomarker disease BEFREE CONCLUSIONS Our results suggest that FGF5 is an independent protective factor for BC patients. 29804124 2018