Benign Prostatic Hyperplasia
|
0.340 |
Biomarker
|
disease |
BEFREE |
Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia.
|
18386288 |
2008 |
Benign Prostatic Hyperplasia
|
0.340 |
Biomarker
|
disease |
CTD_human |
It is concluded that upregulated ERalpha in prostatic stroma may have a greater modulating influence on synthesis of certain growth factors than the direct action of androgens and, by enhancing synthesis of FGF-2 and FGF-7, could play a significant role in the development of BPH.
|
14999240 |
2004 |
Benign Prostatic Hyperplasia
|
0.340 |
Biomarker
|
disease |
BEFREE |
Although the mechanism by which the drugs cause GO is not yet understood, keratinocyte growth factor (KGF), which is a potent epithelial cell mitogen, has been implicated in other hyperplastic conditions, including mammary and prostatic hyperplasia, and could also be involved in the molecular pathology of GO.
|
11453236 |
2001 |
Benign Prostatic Hyperplasia
|
0.340 |
Biomarker
|
disease |
BEFREE |
Effect of a vitamin D3 analogue on keratinocyte growth factor-induced cell proliferation in benign prostate hyperplasia.
|
10902811 |
2000 |
Benign Prostatic Hyperplasia
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
However, KGF, KGF-R, and EGF-R mRNA were not expressed by human fetal prostate; (2) human adult prostate (BPH tissues) showed mRNA transcripts for all growth factors and their receptors except KGF-R; (3) human BPH-1 cell lines expressed mRNA transcripts for TGF-alpha, TGF-beta 1, TGF-beta 2, TGF-beta 3, EGF, and KGF-R, but not for EGF-R and KGF growth factors; (4) human primary prostate cancer cell line (ND-1) showed mRNA transcripts for all growth factors except EGF and KGF; and (5) human prostate cancer cell lines (LNCaP, DU-145, PC-3) expressed mRNA transcripts for all growth factors except KGF, which was absent in all cell lines.
|
8973690 |
1996 |
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
BEFREE |
KGF expressing adenovirus vector, which prevented bleomycin-induced pulmonary fibrosis in a previous study, was constructed.
|
28543309 |
2017 |
Liver Cirrhosis
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Finally, adeno-associated viruses carrying antisense of miR-219-5p were infused into the liver from the mice that had developed cirrhosis by carbon tetrachloride (CCl4), and the effects on KGF levels and liver damage and function were examined.
|
27855391 |
2016 |
Liver Cirrhosis
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Human umbilical cord mesenchymal stem cells ameliorate experimental cirrhosis through activation of keratinocyte growth factor by suppressing microRNA-199.
|
27981544 |
2016 |
Fibrosis, Liver
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Fibroblast growth factor 7 (FGF7) secreted from activated hepatic stellate cells (HSC) during chronic liver fibrosis regulates hepatocyte survival and liver regeneration.
|
22713451 |
2012 |
Prostatic Hyperplasia
|
0.320 |
Biomarker
|
disease |
LHGDN |
Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia.
|
18386288 |
2008 |
Liver Cirrhosis
|
0.320 |
Biomarker
|
disease |
CTD_human |
Differential regulated expression of keratinocyte growth factor and its receptor in experimental and human liver fibrosis.
|
17692400 |
2007 |
Fibrosis, Liver
|
0.320 |
Biomarker
|
disease |
CTD_human |
This study was designed to characterize a putative role of KGF in observed histomorphological changes in both, human and experimental liver fibrosis.
|
17692400 |
2007 |
Fibrosis, Liver
|
0.320 |
Biomarker
|
disease |
BEFREE |
This study was designed to characterize a putative role of KGF in observed histomorphological changes in both, human and experimental liver fibrosis.
|
17692400 |
2007 |
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
CTD_human |
We evaluated in vitro KGF production by human lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF, n = 10) and from control subjects (n = 7) at baseline and after IL-1beta stimulation.
|
15677771 |
2005 |
Pulmonary Fibrosis
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Keratinocyte growth factor expression by fibroblasts in pulmonary fibrosis: poor response to interleukin-1beta.
|
15677771 |
2005 |
Prostatic Hyperplasia
|
0.320 |
Biomarker
|
disease |
CTD_human |
Relationship between upregulated oestrogen receptors and expression of growth factors in cultured, human, prostatic stromal cells exposed to estradiol or dihydrotestosterone.
|
14999240 |
2004 |
Prostatic Hyperplasia
|
0.320 |
Biomarker
|
disease |
BEFREE |
Although the mechanism by which the drugs cause GO is not yet understood, keratinocyte growth factor (KGF), which is a potent epithelial cell mitogen, has been implicated in other hyperplastic conditions, including mammary and prostatic hyperplasia, and could also be involved in the molecular pathology of GO.
|
11453236 |
2001 |
Miscarriage
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We analyzed the expression of FGF7 and FGFR2 and the levels of phosphorylated extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinase (JNK) in endometrial stromal cells (ESCs), and decidual stromal cells (DSCs) from early pregnancy or miscarriage by In-Cell Western assay.
|
28270036 |
2017 |
Miscarriage
|
0.310 |
Biomarker
|
disease |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Cleft upper lip
|
0.310 |
Biomarker
|
disease |
CTD_human |
Sequence evaluation of FGF and FGFR gene conserved non-coding elements in non-syndromic cleft lip and palate cases.
|
17963255 |
2007 |
Cleft upper lip
|
0.310 |
Biomarker
|
disease |
LHGDN |
Impaired FGF signaling contributes to cleft lip and palate.
|
17360555 |
2007 |
Spontaneous abortion
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Lung Injury
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Keratinocyte growth factor protects against Clara cell injury induced by naphthalene.
|
18385170 |
2008 |
Chronic Lung Injury
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Keratinocyte growth factor protects against Clara cell injury induced by naphthalene.
|
18385170 |
2008 |