FGF7, fibroblast growth factor 7, 2252

N. diseases: 167; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
Benign Prostatic Hyperplasia
0.340 Biomarker disease BEFREE Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. 18386288 2008
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
Benign Prostatic Hyperplasia
0.340 Biomarker disease CTD_human It is concluded that upregulated ERalpha in prostatic stroma may have a greater modulating influence on synthesis of certain growth factors than the direct action of androgens and, by enhancing synthesis of FGF-2 and FGF-7, could play a significant role in the development of BPH. 14999240 2004
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
Benign Prostatic Hyperplasia
0.340 Biomarker disease BEFREE Although the mechanism by which the drugs cause GO is not yet understood, keratinocyte growth factor (KGF), which is a potent epithelial cell mitogen, has been implicated in other hyperplastic conditions, including mammary and prostatic hyperplasia, and could also be involved in the molecular pathology of GO. 11453236 2001
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
Benign Prostatic Hyperplasia
0.340 Biomarker disease BEFREE Effect of a vitamin D3 analogue on keratinocyte growth factor-induced cell proliferation in benign prostate hyperplasia. 10902811 2000
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
Benign Prostatic Hyperplasia
0.340 AlteredExpression disease BEFREE However, KGF, KGF-R, and EGF-R mRNA were not expressed by human fetal prostate; (2) human adult prostate (BPH tissues) showed mRNA transcripts for all growth factors and their receptors except KGF-R; (3) human BPH-1 cell lines expressed mRNA transcripts for TGF-alpha, TGF-beta 1, TGF-beta 2, TGF-beta 3, EGF, and KGF-R, but not for EGF-R and KGF growth factors; (4) human primary prostate cancer cell line (ND-1) showed mRNA transcripts for all growth factors except EGF and KGF; and (5) human prostate cancer cell lines (LNCaP, DU-145, PC-3) expressed mRNA transcripts for all growth factors except KGF, which was absent in all cell lines. 8973690 1996
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.320 Biomarker disease BEFREE KGF expressing adenovirus vector, which prevented bleomycin-induced pulmonary fibrosis in a previous study, was constructed. 28543309 2017
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.320 AlteredExpression disease BEFREE Finally, adeno-associated viruses carrying antisense of miR-219-5p were infused into the liver from the mice that had developed cirrhosis by carbon tetrachloride (CCl4), and the effects on KGF levels and liver damage and function were examined. 27855391 2016
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.320 AlteredExpression disease BEFREE Human umbilical cord mesenchymal stem cells ameliorate experimental cirrhosis through activation of keratinocyte growth factor by suppressing microRNA-199. 27981544 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.320 AlteredExpression disease BEFREE Fibroblast growth factor 7 (FGF7) secreted from activated hepatic stellate cells (HSC) during chronic liver fibrosis regulates hepatocyte survival and liver regeneration. 22713451 2012
CUI: C2937421
Disease: Prostatic Hyperplasia
Prostatic Hyperplasia
0.320 Biomarker disease LHGDN Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. 18386288 2008
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.320 Biomarker disease CTD_human Differential regulated expression of keratinocyte growth factor and its receptor in experimental and human liver fibrosis. 17692400 2007
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.320 Biomarker disease CTD_human This study was designed to characterize a putative role of KGF in observed histomorphological changes in both, human and experimental liver fibrosis. 17692400 2007
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.320 Biomarker disease BEFREE This study was designed to characterize a putative role of KGF in observed histomorphological changes in both, human and experimental liver fibrosis. 17692400 2007
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.320 Biomarker disease CTD_human We evaluated in vitro KGF production by human lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF, n = 10) and from control subjects (n = 7) at baseline and after IL-1beta stimulation. 15677771 2005
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.320 AlteredExpression disease BEFREE Keratinocyte growth factor expression by fibroblasts in pulmonary fibrosis: poor response to interleukin-1beta. 15677771 2005
CUI: C2937421
Disease: Prostatic Hyperplasia
Prostatic Hyperplasia
0.320 Biomarker disease CTD_human Relationship between upregulated oestrogen receptors and expression of growth factors in cultured, human, prostatic stromal cells exposed to estradiol or dihydrotestosterone. 14999240 2004
CUI: C2937421
Disease: Prostatic Hyperplasia
Prostatic Hyperplasia
0.320 Biomarker disease BEFREE Although the mechanism by which the drugs cause GO is not yet understood, keratinocyte growth factor (KGF), which is a potent epithelial cell mitogen, has been implicated in other hyperplastic conditions, including mammary and prostatic hyperplasia, and could also be involved in the molecular pathology of GO. 11453236 2001
CUI: C4552766
Disease: Miscarriage
Miscarriage
0.310 AlteredExpression disease BEFREE We analyzed the expression of FGF7 and FGFR2 and the levels of phosphorylated extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinase (JNK) in endometrial stromal cells (ESCs), and decidual stromal cells (DSCs) from early pregnancy or miscarriage by In-Cell Western assay. 28270036 2017
CUI: C4552766
Disease: Miscarriage
Miscarriage
0.310 Biomarker disease CTD_human Gene expression in cultured endometrium from women with different outcomes following IVF. 18539642 2008
CUI: C0008924
Disease: Cleft upper lip
Cleft upper lip
0.310 Biomarker disease CTD_human Sequence evaluation of FGF and FGFR gene conserved non-coding elements in non-syndromic cleft lip and palate cases. 17963255 2007
CUI: C0008924
Disease: Cleft upper lip
Cleft upper lip
0.310 Biomarker disease LHGDN Impaired FGF signaling contributes to cleft lip and palate. 17360555 2007
CUI: C0000786
Disease: Spontaneous abortion
Spontaneous abortion
0.300 Biomarker phenotype CTD_human Gene expression in cultured endometrium from women with different outcomes following IVF. 18539642 2008
CUI: C0000822
Disease: Abortion, Tubal
Abortion, Tubal
0.300 Biomarker phenotype CTD_human Gene expression in cultured endometrium from women with different outcomes following IVF. 18539642 2008
CUI: C0273115
Disease: Lung Injury
Lung Injury
0.300 Therapeutic disease CTD_human Keratinocyte growth factor protects against Clara cell injury induced by naphthalene. 18385170 2008
CUI: C2350344
Disease: Chronic Lung Injury
Chronic Lung Injury
0.300 Therapeutic disease CTD_human Keratinocyte growth factor protects against Clara cell injury induced by naphthalene. 18385170 2008