|
Hand deformities
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In addition to hypogonadotropic hypogonadism, 44.4% (8/18) patients exhibited other clinical deformities, including dental agenesis (3/18, 16.7%), hearing loss (3/18, 16.7%), and hand malformation (2/18, 11.1%). hCG/hMG therapy was effective in promoting sexual development in IHH patients with FGFR1, FGF8, and FGF17 mutations.
|
31748124 |
2020 |
|
Congenital Hand Deformities
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In addition to hypogonadotropic hypogonadism, 44.4% (8/18) patients exhibited other clinical deformities, including dental agenesis (3/18, 16.7%), hearing loss (3/18, 16.7%), and hand malformation (2/18, 11.1%). hCG/hMG therapy was effective in promoting sexual development in IHH patients with FGFR1, FGF8, and FGF17 mutations.
|
31748124 |
2020 |
|
Rectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of this study suggest that FGF8 and Survivin contribute to radiation resistance in rectal cancer and may serve as markers to select patients who may not benefit from neoadjuvant radiotherapy.
|
30276721 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we review the involvement of FGFs in bone-related processes and diseases; FGF1 in the differentiation of human bone marrow mesenchymal stem cells and fracture repair; FGF2, FGF9, and FGF18 in osteoarthritis; FGF6 in bone and muscle injury; FGF8 in osteoarthritis and Kashin-Beck disease; and FGF21 and FGF23 on bone regulation.
|
31260189 |
2019 |
|
Deformity
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Patients with hypospadias consistently showed aberrant immunohistochemical staining patterns for FGF8/FGF10/FGFR2 in epidermis and dermis compared to patients without penile malformation (p < 0.01 for all markers). qPCR displayed no difference in expression levels on mRNA level (FGFR2 p = 0.44, FGF8 p = 0.77, and FGF10 p = 0.17) comparing normal foreskin with foreskin from patients with hypospadias.Figure.
|
31718875 |
2019 |
|
Amputated structure (morphologic abnormality)
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Supplementation of nerve factors BMP7, FGF2, and FGF8 in the stump ends after amputation on denervated limbs not only enabled HDAC1 up-regulation but also led to more extent of limb regeneration.
|
30826398 |
2019 |
|
Neural Tube Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
We also discuss the role of Cubilin as a modulator of Fgf8 signaling during embryonic development and propose that the Cubilin-Fgf8 interaction may be relevant in human pathology, including in cancer progression, heart or neural tube defects.
|
30295181 |
2018 |
|
Odontogenic Cysts
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Dental organs of various odontogenic stages and 30 OTs including solid multicystic ameloblastomas (SMA, 10 cases), ameloblastic fibroma (AF, 10 cases), odontogenic myxoma (OM, 10 cases), and odontogenic cysts: odontogenic keratocyst (OKC, 10 cases) were evaluated in both epithelial and mesenchymal components for the expression of BMP4 and FGF8 using immunohistochemistry.
|
30079292 |
2018 |
|
Odontogenic Tumors
|
0.010 |
Biomarker
|
group |
BEFREE |
The mesenchymal nuclear expression of both BMP4 (8 cases) (<i>p</i> = 0.001) and FGF8 (9 cases) (<i>p</i> = 0.045) were significantly high in OMs among all OTs.
|
30079292 |
2018 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We also discuss the role of Cubilin as a modulator of Fgf8 signaling during embryonic development and propose that the Cubilin-Fgf8 interaction may be relevant in human pathology, including in cancer progression, heart or neural tube defects.
|
30295181 |
2018 |
|
Odontogenic myxoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Dental organs of various odontogenic stages and 30 OTs including solid multicystic ameloblastomas (SMA, 10 cases), ameloblastic fibroma (AF, 10 cases), odontogenic myxoma (OM, 10 cases), and odontogenic cysts: odontogenic keratocyst (OKC, 10 cases) were evaluated in both epithelial and mesenchymal components for the expression of BMP4 and FGF8 using immunohistochemistry.
|
30079292 |
2018 |
|
Jaw Keratocyst
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Dental organs of various odontogenic stages and 30 OTs including solid multicystic ameloblastomas (SMA, 10 cases), ameloblastic fibroma (AF, 10 cases), odontogenic myxoma (OM, 10 cases), and odontogenic cysts: odontogenic keratocyst (OKC, 10 cases) were evaluated in both epithelial and mesenchymal components for the expression of BMP4 and FGF8 using immunohistochemistry.
|
30079292 |
2018 |
|
Endometrial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
One subfamily of the fibroblast growth factor (FGF) superfamily, namely the FGF8 subfamily (including FGF17 and FGF18), has become important as Fgf8 has been described as an oocyte-derived factor essential for glycolysis in mouse cumulus cells and aberrant expression of <i>FGF18</i> has been described in ovarian and endometrial cancers.
|
29269444 |
2018 |
|
Keratocystic Odontogenic Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Dental organs of various odontogenic stages and 30 OTs including solid multicystic ameloblastomas (SMA, 10 cases), ameloblastic fibroma (AF, 10 cases), odontogenic myxoma (OM, 10 cases), and odontogenic cysts: odontogenic keratocyst (OKC, 10 cases) were evaluated in both epithelial and mesenchymal components for the expression of BMP4 and FGF8 using immunohistochemistry.
|
30079292 |
2018 |
|
Kashin-Beck Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
FGF8 and FGFR3 may therefore play an important role in the onset of deep zone necrosis and pathogenesis in KBD in adolescent children.
|
29626475 |
2018 |
|
CHARGE Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The altered cerebellar foliation pattern in Chd7 haploinsufficient mice show some similarities to those reported in mice with altered Engrailed, Fgf8 or Zic1 gene expression and we propose that mutations or polymorphisms in these genes may modify the cerebellar phenotype in CHARGE syndrome.
|
29168327 |
2017 |
|
Chronic Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In conclusion, variant/s in FGF2 and FGF8 may predispose diabetics with CKD to LEA.
|
27237708 |
2016 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Molecular validation demonstrated that FGF8 fully induced nuclear localization of YAP1 and enhanced transcriptional outcomes such as the expression of CTGF and CYR61, while decreasing YAP1 expression impeded FGF-8-induced cell growth, EMT, migration and invasion, revealing that YAP1 is required for FGF8-mediated CRC growth and metastasis.
|
25473897 |
2015 |
|
Nephroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
WT1 controls metanephric mesenchyme (MM) self-renewal and proliferation mainly by regulating FGF and BMP-pSMAD signaling pathways as well as Sall1 and Pax2, encoding key transcription factors; WT1 drives MM differentiation and mesenchyme-epithelial transition by targeting Fgf8 and Wnt4; WT1 defines podocyte identity by activation of other podocyte-specific transcription factors, including Mafb, Lmx1b, FoxC2, and Tcf21.
|
26154924 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
FGF8 promotes colorectal cancer growth and metastasis by activating YAP1.
|
25473897 |
2015 |
|
Hypogonadism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Micropenis in patients with FGF8 abnormalities appears to be caused by gonadotropin deficiency and defective outgrowth of the anlage of the penis.
|
24280688 |
2014 |
|
Myxoinflammatory fibroblastic sarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Distinct and reproducible genetic abnormalities identified in MIFS are translocation t(1;10)(p22:q24), with rearrangements of the TGFBR3 and MGEA5 genes associated with increased levels of FGF8, and formation of marker/ring chromosome 3, with amplification of the VGLL3 locus.
|
25268202 |
2014 |
|
VATER/VACTERL ASSOCIATION
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest FGF8 mutations to contribute to the formation of the VATER/VACTERL association.
|
25131394 |
2014 |
|
Micropenis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Micropenis in patients with FGF8 abnormalities appears to be caused by gonadotropin deficiency and defective outgrowth of the anlage of the penis.
|
24280688 |
2014 |
|
Gonadotropin deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Micropenis in patients with FGF8 abnormalities appears to be caused by gonadotropin deficiency and defective outgrowth of the anlage of the penis.
|
24280688 |
2014 |