|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
To clarify the function of FGF-2 in the malignancy of tumor cells, we designed experiments to express antisense RNA in a hepatoma cell line.
|
7585554 |
1995 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
To clarify the function of FGF-2 in the malignancy of tumor cells, we designed experiments to express antisense RNA in a hepatoma cell line.
|
7585554 |
1995 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results clearly argue for a key role of endogenous FGF-2 in transformation and tumorigenesis of the hepatoma cell line used in this study.
|
7585554 |
1995 |
|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These results clearly argue for a key role of endogenous FGF-2 in transformation and tumorigenesis of the hepatoma cell line used in this study.
|
7585554 |
1995 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results clearly argue for a key role of endogenous FGF-2 in transformation and tumorigenesis of the hepatoma cell line used in this study.
|
7585554 |
1995 |
|
Tumor Angiogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Breast carcinomas expressing elevated eIF-4E also exhibited the large FGF-2 isoforms, which could play an important role in tumor angiogenesis.
|
8570185 |
1995 |
|
Neoplasm Metastasis
|
0.380 |
AlteredExpression
|
phenotype |
BEFREE |
To investigate whether growth, invasion and metastasis of endometrial cancer cells is associated with neovascularization, the expressions of fibroblast growth factor-1 (acidic FGF), -2 (basic FGF) and -4 (hst-1) mRNAs and FGF-2 in endometrial cancers and normal endometria as controls were determined by reverse transcription-polymerase chain reaction-Southern blot and ELISA, respectively, and the relationships between their expressions and histological grades, grades of myometrial invasion or clinical stages of endometrial cancers were analyzed.
|
8685603 |
1996 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The levels of FGF-1 mRNA and FGF-2 and its mRNA tended to increase with dedifferentiation (especially grade G3), myometrial invasion (especially grade C) and staging (especially stages III and IV) in endometrial cancers were significantly (p < 0.05) higher than those in normal endometria.
|
8685603 |
1996 |
|
Anaplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The levels of FGF-1 mRNA and FGF-2 and its mRNA tended to increase with dedifferentiation (especially grade G3), myometrial invasion (especially grade C) and staging (especially stages III and IV) in endometrial cancers were significantly (p < 0.05) higher than those in normal endometria.
|
8685603 |
1996 |
|
Malignant neoplasm of endometrium
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To investigate whether growth, invasion and metastasis of endometrial cancer cells is associated with neovascularization, the expressions of fibroblast growth factor-1 (acidic FGF), -2 (basic FGF) and -4 (hst-1) mRNAs and FGF-2 in endometrial cancers and normal endometria as controls were determined by reverse transcription-polymerase chain reaction-Southern blot and ELISA, respectively, and the relationships between their expressions and histological grades, grades of myometrial invasion or clinical stages of endometrial cancers were analyzed.
|
8685603 |
1996 |
|
Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The levels of FGF-1 mRNA and FGF-2 and its mRNA tended to increase with dedifferentiation (especially grade G3), myometrial invasion (especially grade C) and staging (especially stages III and IV) in endometrial cancers were significantly (p < 0.05) higher than those in normal endometria.
|
8685603 |
1996 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Characterisation of the spatial distribution of the FGFR multigene family in both normal and atherosclerotic arteries is a prerequisite to further define the functional role of FGF-1 and FGF-2 in atherosclerosis.
|
8881516 |
1996 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Characterisation of the spatial distribution of the FGFR multigene family in both normal and atherosclerotic arteries is a prerequisite to further define the functional role of FGF-1 and FGF-2 in atherosclerosis.
|
8881516 |
1996 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells.
|
8883950 |
1996 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells.
|
8883950 |
1996 |
|
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells.
|
8883950 |
1996 |
|
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells.
|
8883950 |
1996 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas.
|
9285563 |
1997 |
|
Ductal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We report that eIF4E is markedly increased in vascularized malignant ductules of invasive carcinomas, whereas necrotic and avascular ductal carcinomas in situ display significantly lower levels. eIF4E facilitates the synthesis of FGF-2, a powerful tumor angiogenic factor.
|
9285563 |
1997 |
|
Tumor Progression
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
We examined the expression of FGF-2 mRNA in 16 early and 14 advanced gastric cancer by in situ hybridisation to elucidate its role in cancer progression.
|
9490085 |
1997 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that FGF-2 may play an important role for the growth of diffuse type gastric cancers, particularly at their advanced stage.
|
9490085 |
1997 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined the expression of FGF-2 mRNA in 16 early and 14 advanced gastric cancer by in situ hybridisation to elucidate its role in cancer progression.
|
9490085 |
1997 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of FGF-2 in placenta and its presence in maternal blood are elevated in pregnancies complicated by diabetes and are greatest in diabetic pregnancies associated with retinopathy.
|
9704229 |
1998 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The expression of FGF-2 in placenta and its presence in maternal blood are elevated in pregnancies complicated by diabetes and are greatest in diabetic pregnancies associated with retinopathy.
|
9704229 |
1998 |
|
Pregnancy in Diabetics
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The expression of FGF-2 in placenta and its presence in maternal blood are elevated in pregnancies complicated by diabetes and are greatest in diabetic pregnancies associated with retinopathy.
|
9704229 |
1998 |