Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
To explore the anti-cerebral ischemia effect and clarify the therapeutic mechanism of SalA, SH-SY5Y cells and Sprague-Dawley rats were applied, which were exposed to oxygen glucose deprivation/reoxygenation (OGD/R) and middle cerebral artery occlusion/reperfusion (MCAO/R) injuries, respectively.
|
31193821 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo mouse model of CIS induced by middle cerebral artery occlusion and in vitro model induced by oxygen-glucose deprivation/reoxygenation (OGD/R) in N2A cells was established.
|
30327244 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo middle cerebral artery occlusion (MCAO) rat model and in vitro oxygen-glucose deprivation/reperfusion (OGD/R)-treated neurocytes model were generated.
|
31794744 |
2020 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
To explore the neuroprotective effects of an aqueous extract of Radix Scrophulariae (RSAE) on cerebral ischemia/reperfusion and their underlying mechanisms, oxygen-glucose deprivation and reperfusion (OGD/R)-induced PC12 cells were used, and a middle cerebral artery occlusion/reperfusion (MCAO/R) mouse model was established.
|
30235876 |
2018 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, CID downregulated the protein levels of Lamp1 and active cathepsin B in astrocytes after OGD/Re or tMCAO injury; CID inhibited the co-localization of cathepsin B and Rab7, Lamp1 and Rab7; CID decreased OGD/Re-induced increase in lysosomal membrane permeability and blocked OGD/Re-induced release of cathepsin B from the lysosome into the cytoplasm in astrocytes.
|
30315251 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used middle cerebral artery occlusion/reperfusion (MCAO/R) and oxygen-glucose deprivation/reoxygenation (OGD/R) models mimicking the process of ischemia/reperfusion in vivo and in vitro, respectively.
|
31678414 |
2020 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oxygen-glucose deprivation/reoxygenation (OGD/R) in cells and middle cerebral artery occlusion/reperfusion (MCAO/R) in mice were performed to simulate an ischemic stroke environment.
|
30419554 |
2018 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
Middle cerebral artery occlusion/reperfusion (MCAO/R) model in adult male Sprague Dawley rats (250-280 g) were established and cultured neurons were exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) to mimic I/R injury <i>in vitro</i>.
|
29163033 |
2017 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies were carried out in transient middle cerebral artery occlusion (MCAO) in rats and oxygen glucose deprivation/reoxygenation (OGD/R) in primary cortical neurons.
|
28602833 |
2017 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
Preclinical efficacy of rT3 as a neuroprotective agent was determined in rat model of middle cerebral artery occlusion (MCAO) induced cerebral IR and in oxygen glucose deprivation/reoxygenation (OGD/R) model in vitro. rT3 administration in rats significantly reduced neuronal injury markers, infarct size and neurological deficit upon ischemic insult.
|
30366665 |
2018 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study explored whether panax notoginseng saponins (PNS) provided neuroprotective effects by inhibiting the expressions of NgR1, RhoA, and ROCK2 following middle cerebral artery occlusion in rats and oxygen-glucose deprivation/reoxygenation (OGD/R) injury in SH-SY5Y cells.
|
27288754 |
2016 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Middle cerebral artery occlusion method (MCAO) and oxygen and glucose deprivation/reoxygenation (OGD/R) method were used to simulate cerebral I/R injury in Sprague-Dawley (SD) rats and HT22 cells, respectively.
|
31086091 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
Middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation/reoxygenation (OGD/R) are models that are commonly used to study ischemic stroke.
|
29390963 |
2018 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we use the middle cerebral artery occlusion/reperfusion (MCAO/R) model in rats and oxygen glucose deprivation/reoxygenation (OGD/R) model in fetal rat primary cortical neurons to investigate whether and how S-oxiracetam (S-ORC) protect brain injury from ischemic stroke.
|
29355569 |
2018 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cerebral I/R injury was induced in the Sprague Dawley (SD) rats by middle cerebral artery occlusion (MCAO) and reperfusion and in murine hippocampal neuronal cells (HT22) by oxygen-glucose deprivation/reperfusion (OGD/R) stimulation.
|
31298343 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
To the best of our knowledge, no investigation has systematically examined the expression changes of microRNA (miR)-449a and Amphiregulin (AREG) as well as their biological relationship during middle cerebral artery occlusion (MCAO) and oxygen and glucose deprivation/reperfusion (OGD/R).
|
30773606 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
The OGD/R or middle cerebral artery occlusion/reperfusion (MCAO/R)-treated neurons was used to simulate ischemia/reperfusion injury .
|
31081172 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we established middle cerebral artery occlusion/reperfusion (MCAO/R) model in mice and adopted oxygen-glucose deprivation and reperfusion (OGD/R) SH-SY5Y cell model to mimic cerebral I/R injury in vitro.
|
31056262 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study is to explore whether Swe could prevent brain from I/R injury, and the related mechanisms of oxidative stress are also elucidated using mice middle cerebral artery occlusion (MCAO) model and primary hippocampal neurons oxygen-glucose deprivation/reperfusion (OGD/R) model.
|
30753053 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we found that miR-874-3p levels significantly decreased in rat I/R brain induced by middle cerebral artery occlusion/reperfusion (MCAO/R) and SH-SY5Y cells following oxygen-glucose deprivation and reperfusion (OGD/R) treatment.
|
31200256 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Methyllycaconitine treatment increased cytomembrane FGFR1 expression and GFAP/BrdU-positive cells, upregulated the levels of phosphoinositide 3-kinase (PI3K) and phospho-Akt (pAkt), decreased nuclear FGFR1 expression, decreased the number of DCX-positive cells, and reduced the levels of DCX, PSA-NCAM, and Mash1 in the SVZ of MCAO mice compared with levels in vehicle-treated MCAO mice.
|
28551702 |
2017 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
A middle cerebral artery occlusion-reperfusion (MCAO/R) mouse model and HT22/U251 co-culture model subjected to oxygen-glucose deprivation and re-introduction (OGD/R) were employed, with or without PTE treatment.
|
31681297 |
2019 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used the middle cerebral artery occlusion (MCAO) rat model as well as oxygen and glucose deprivation-reoxygenation (OGD/R) endothelial cells as ischemic stroke models to investigate the efficacy and mechanisms of treating ischemic stroke with the combination of GBC and TH.
|
30090656 |
2018 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we reported that the expression of casein kinase 2 (CK2) was significantly reduced in brains of middle cerebral artery occlusion/reperfusion (MACO/R) model rats and oxygen-glucose deprivation/reperfusion (OGD/R) model neurons, which was associated with the activation of eIF2-ATF4-CHOP signaling pathway, leading to neuronal apoptosis.
|
29337146 |
2018 |
Middle Cerebral Artery Occlusion
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study aimed to explore the potential neuroprotective effects of SVHRP on cerebral ischemia/reperfusion (I/R) injury, using a mouse model of middle cerebral artery occlusion/reperfusion (MCAO/R) and a cellular model of oxygen-glucose deprivation/reoxygenation (OGD/R).
|
31502213 |
2020 |