Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
FGFR1 has been implicated in numerous cancer types including squamous cell lung cancer, a subset of non-small cell lung cancer with a dismal 5-year survival rate.
|
30257990 |
2019 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our work therefore provides a rationale for the inhibition of MCL-1, BCL-XL, and FGFR1 to maximize therapeutic response in FGFR1-expressing lung SqCC.
|
29743589 |
2018 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, we detected subclonal <i>NRAS</i> amplifications in 3 of 20 (15%) primary human <i>FGFR1</i>-amplified SQLC specimens.
|
28630215 |
2017 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor receptor 1 (FGFR1) has been demonstrated to be a high-frequency targetable oncogene specific for smoking-associated lung cancers, present in over 20% of lung squamous cell carcinoma cases.
|
28483948 |
2017 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Amplification of fibroblast growth factor receptor 1 (FGFR1) is one of the most frequent targets in lung squamous cell carcinoma (SQCC).
|
28558758 |
2017 |
Squamous cell carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Enhancement of the anti-tumor activity of FGFR1 inhibition in squamous cell lung cancer by targeting downstream signaling involved in glucose metabolism.
|
29190880 |
2017 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
FGFR1 amplification is more prevalent in late stage SQC patients but does not predict chemotherapy response.
|
28008744 |
2017 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Frequency of FGFR1 amplification is similar in SqCC with and without lymph node metastases, but status in metastatic sites may be discordant from the primary in a small subset of cases, which may affect the decision to perform testing of metastatic SqCCs.
|
26712871 |
2016 |
Squamous cell carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
FGFR1 CNG (10.7%), FGFR1 mutation (2.7%), FGFR2 mutation (2.7%), FGFR4 mutation (5.3%), and FGFR3 fusion (1.3%) were detected in LSCC specimens by NGS.
|
27581340 |
2016 |
Squamous cell carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We show that SOX2 but not FGFR1 overexpression in tracheobronchial basal cells combined with Cdkn2ab and Pten loss results in LSCC closely resembling the human counterpart.
|
27728803 |
2016 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to evaluate FGFR1, PIK3CA and SOX2 protein expression in SQCC and determine whether the expression of these can be used as prognostic biomarkers.
|
25384882 |
2015 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
This meta-analysis strongly suggests that FGFR1 amplification occurs more frequently in male, SQCC and smokers, and it is a risk factor for poor prognosis among Asian patients with SQCC.
|
26788508 |
2015 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Eligible studies regarding incidence of FGFR1 amplification in lung SQCC and correlation between FGFR1 amplification and clinicopathological features or survival were extracted and analyzed.
|
25433983 |
2015 |
Squamous cell carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to elucidate if these tumors harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, which has recently been identified as a potential therapeutic target in squamous cell lung cancer.
|
23913758 |
2014 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this issue of Cancer Discovery, Malchers and colleagues perform a detailed characterization of 8p12 in squamous cell lung cancer and find remarkable genomic heterogeneity in this region, raising the possibility that other genes in addition to FGFR1 may play a role in squamous cell lung cancer.
|
24501305 |
2014 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, the fibroblast growth factor receptor 1 (FGFR1) has been identified as the first actionable target in squamous cell lung cancer.
|
24584974 |
2014 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the FGFR1 amplification patterns in SCLC differs strongly from the previously described FGFR1 amplification pattern in squamous cell carcinoma of the lung, as positive SCLC harbor mostly homogeneous high-level amplifications.
|
23887299 |
2014 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review focuses on the emerging role of FGFR1 as a therapeutic target in lung squamous cell carcinoma and reviews current agents that are in clinical development for the treatment of FGFR-dependent cancer.
|
23469973 |
2013 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
FGFR1 amplification is not prognostic in resected lung squamous cell carcinoma patients.
|
24077455 |
2013 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fibroblast Growth Factor Receptor 1 (FGFR1) amplification frequently occurs in squamous cell carcinoma of the lung and represents a novel druggable therapeutic target in this and other malignancies.
|
23434054 |
2013 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
More recently oncogenic drivers, such as DDR2, FGFR1 and PI3KCA, have been characterized in squamous cell lung carcinoma (SCC) and target agents are currently under evaluation.
|
23930754 |
2013 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, we characterized fibroblast growth factor receptor 1 amplification as a target for a rational therapy in lung squamous cell carcinoma.
|
23619603 |
2013 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer.
|
23182986 |
2013 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
FGFR1 amplification is a common genetic event occurring at a frequency of 16% in L-SCCs.
|
22499828 |
2012 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer.
|
22684217 |
2012 |