Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE In the future, FGFR1 inhibitors might be specific and effective therapeutic targets for EMS. 29614500 2019
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE The 8p11 myeloproliferative syndrome (EMS), a rare myeloproliferative disease, generally progresses rapidly and is characterized by chromosomal translocations of the fibroblast growth factor receptor 1 (FGFR1) gene. 30116393 2018
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE It is important to recognize that neoplasms carrying the t(8;22)/BCR-FGFR1, although rare, can commonly with B lymphoblastic leukemia at the initial diagnosis, which could distract one from recognizing a possible underlying 8p11 myeloproliferative syndrome. 28551329 2017
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE To identify the most promising drug for EMS, the activities and associated mechanism of three tyrosine kinase inhibitors (TKIs), TKI258, ponatinib and AZD4547, against TPR‑FGFR1 were tested by MTT assay, flow cytometry and western blot. 28138694 2017
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE Primary cells in BCR/FGFR1-positive 8p11 myeloproliferative syndrome are sensitive to dovitinib, ponatinib, and dasatinib. 28881484 2017
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE Diagnostic application of next-generation sequencing in ZMYM2-FGFR1 8p11 myeloproliferative syndrome: A case report. 27415155 2016
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE Furthermore, TPR-FGFR1 enables cytokine-independent survival, proliferation, and granulocytic differentiation of the interleukin-3 dependent myeloid progenitor cell line 32Dcl3, reflecting the chronic phase of EMS characterized by myeloid hyperplasia. 26391436 2016
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 AlteredExpression disease BEFREE The 8p11 myeloproliferative syndrome (EMS) is an aggressive chronic myeloproliferative disorder (MPD) that is caused by constitutive activation of fibroblast growth factor receptor 1. 25803811 2015
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE Of the 2 cases of EMS with t(1;8)(q25;p11.2) which were previously reported, FGFR1 rearrangement was not confirmed in 1 case. 25227135 2015
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE Chromosomal translocation of FGFR1 occurs in the 8p11 myeloproliferative syndrome and alveolar rhabdomyosarcoma, as with FGFR3 in multiple myeloma and peripheral T-cell lymphoma. 23696246 2014
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE The 8p11 myeloproliferative syndrome is an aggressive neoplasm associated with chromosomal abnormalities involving rearrangement of the fibroblast growth factor receptor 1 (FGFR1) gene. 25037443 2014
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE Ponatinib as targeted therapy for FGFR1 fusions associated with the 8p11 myeloproliferative syndrome. 22875613 2013
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE A case of 8p11 myeloproliferative syndrome with BCR-FGFR1 gene fusion presenting with trilineage acute leukemia/lymphoma, successfully treated by cord blood transplantation. 23171834 2013
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE The 8p11 myeloproliferative syndrome is a rare atypical disorder defined by the presence of rearrangements between the fibroblast growth factor receptor 1 (FGFR1) and 1 of 13 partner genes described to date, including the BCR gene on chromosome 22. 23519513 2013
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE Favorable outcome of allogeneic hematopoietic cell transplantation for 8p11 myeloproliferative syndrome associated with BCR-FGFR1 gene fusion. 22106025 2012
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE Our results further support a critical role of FGFR1 in the pathogenesis of EMS and may lead to more accurate diagnosis and potential targeted therapy. 22619110 2012
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE In summary, we identified a novel CUX1-FGFR1 fusion oncogene in a patient with the 8p11 myeloproliferative syndrome and demonstrated its transforming potential in the Ba/F3 cell line. 21330321 2011
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE In the future, FGFR1 inhibitor might be the specific and effective therapeutic target for EMS. 21214407 2011
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE In immunodeficient mice, expression of ZMYM2/FGFR1 or BCR/FGFR1 in human cells induces several features of human EMS, including expansion of several myeloid cell lineages and accumulation of blasts in bone marrow. 20554971 2010
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE In the current World Health Organization classification, the 8p11 myeloproliferative syndrome is designated as "myeloid and lymphoid neoplasms with FGFR1 abnormalities." 20226962 2010
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE The 8p11 myeloproliferative syndrome is a rare hematologic malignancy derived from a pluripotent hematopoietic stem cell associated with rearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene located on chromosome 8p11. 19829149 2009
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE We report a rare case of t(8;9)(p11;q33) in a patient with 8p11 myeloproliferative syndrome (EMS) that was preceded by centrosomal protein 110kDa (CEP110; previously CEP1)/fibroblast growth factor receptor 1 (FGFR1) fusion transcript. 18295660 2008
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 Biomarker disease BEFREE Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome. 17698633 2007
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE In the present study, we have investigated a case of EMS harboring a t(8;22)(p11;q11)/BCR-FGFR1 rearrangement as well as a t(9;21)(q34;q22) at the time of AML transformation. 17394134 2007
Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
0.100 GeneticVariation disease BEFREE A biphenotypic transformation of 8p11 myeloproliferative syndrome with CEP1/FGFR1 fusion gene. 16879608 2006