|
Post-Traumatic Stress Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the potential of ACH-000029 to prevent anxiety-like behavior in the single prolonged stress (SPS) PTSD model.
|
31843397 |
2020 |
|
Skin Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In human and murine epidermis, FGF receptor 3 (FGFR3) activation causes benign skin tumours, but the consequences of FGFR3 deficiency in this tissue have not been determined.
|
31830366 |
2020 |
|
Inflammatory dermatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the defect in the epidermal barrier and the resulting inflammatory skin disease that develops in mice lacking FGFR1 and FGFR2 in keratinocytes were further aggravated upon additional loss of FGFR3.
|
31830366 |
2020 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our previous study demonstrated that fibroblast growth factor receptor 3 (FGFR3) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit a (PIK3CA) are often mutated in HPV<sup>+</sup> cancer.
|
31788102 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our previous study demonstrated that fibroblast growth factor receptor 3 (FGFR3) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit a (PIK3CA) are often mutated in HPV<sup>+</sup> cancer.
|
31788102 |
2019 |
|
Small Fiber Neuropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Auto-antibodies targeting neuronal antigens trisulfated heparin disaccharide (TS-HDS) and fibroblast growth factor 3 (FGFR3) are found in up to 20% of patients with SFN.
|
31773305 |
2019 |
|
Sensory neuropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies.
|
31690697 |
2020 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study identifies the role of FGFR3 in synovial macrophage recruitment and synovitis, which provides a new insight into the pathological mechanisms of inflammation-related arthritis.
|
31662319 |
2020 |
|
Synovitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study identifies the role of FGFR3 in synovial macrophage recruitment and synovitis, which provides a new insight into the pathological mechanisms of inflammation-related arthritis.
|
31662319 |
2020 |
|
Neoplasms
|
0.200 |
AlteredExpression
|
group |
BEFREE |
The aim of this study was to uncover the expression of FGFR1 and FGFR3 proteins in choroid plexus tumors and to further characterize FGFR-related as well as other genetic alterations in FGFR3 expressing tumors.
|
31660579 |
2019 |
|
Ependymoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Among gliomas, FGFR3 fusions occur in IDH wild-type diffuse gliomas leading to high FGFR3 protein expression and both, FGFR3 and FGFR1, show elevated expression in aggressive ependymomas.
|
31660579 |
2019 |
|
Choroid Plexus Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
FGFR3 and FGFR1 proteins are expressed in a subpopulation of choroid plexus tumors.
|
31660579 |
2019 |
|
Immune System Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Autoantibodies directed against TS-HDS and FGFR-3 suggest an immune disorder in otherwise idiopathic SFN.
|
31650561 |
2020 |
|
Neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CAST‑PCR detected one FGFR3 mutation in 1/29 NBs.
|
31638167 |
2019 |
|
Central neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines.
|
31638167 |
2019 |
|
Childhood Neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines.
|
31638167 |
2019 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
In the MCC xenografts mice, knockdown of FGFR3 decreased tumor growth and metastasis.
|
31619201 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FGFR3 promotes the growth and malignancy of melanoma by influencing EMT and the phosphorylation of ERK, AKT, and EGFR.
|
31619201 |
2019 |
|
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been linked to tumor progression in many types of cancer.
|
31619201 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
FGFR3 promotes the growth and malignancy of melanoma by influencing EMT and the phosphorylation of ERK, AKT, and EGFR.
|
31619201 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
FGFR3 knockdown and overexpression strategies were employed to investigate the effects of FGFR3 on colony formation, cell apoptosis, proliferation, migration, and in vitro invasion, along with the growth and metastasis of melanoma in a xenografts mouse model.
|
31619201 |
2019 |
|
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
FGFR3 knockdown and overexpression strategies were employed to investigate the effects of FGFR3 on colony formation, cell apoptosis, proliferation, migration, and in vitro invasion, along with the growth and metastasis of melanoma in a xenografts mouse model.
|
31619201 |
2019 |
|
melanoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
FGFR3 knockdown and overexpression strategies were employed to investigate the effects of FGFR3 on colony formation, cell apoptosis, proliferation, migration, and in vitro invasion, along with the growth and metastasis of melanoma in a xenografts mouse model.
|
31619201 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
FGFR3 expression in cutaneous malignant melanoma (CMM) tissues was positively correlated with the Breslow thickness and lymph node metastasis.
|
31619201 |
2019 |
|
Cutaneous Melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FGFR3 expression in cutaneous malignant melanoma (CMM) tissues was positively correlated with the Breslow thickness and lymph node metastasis.
|
31619201 |
2019 |