Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study identifies the role of FGFR3 in synovial macrophage recruitment and synovitis, which provides a new insight into the pathological mechanisms of inflammation-related arthritis.
|
31662319 |
2020 |
Immune System Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Autoantibodies directed against TS-HDS and FGFR-3 suggest an immune disorder in otherwise idiopathic SFN.
|
31650561 |
2020 |
Post-Traumatic Stress Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the potential of ACH-000029 to prevent anxiety-like behavior in the single prolonged stress (SPS) PTSD model.
|
31843397 |
2020 |
Synovitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study identifies the role of FGFR3 in synovial macrophage recruitment and synovitis, which provides a new insight into the pathological mechanisms of inflammation-related arthritis.
|
31662319 |
2020 |
Sensory neuropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies.
|
31690697 |
2020 |
Inflammatory dermatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the defect in the epidermal barrier and the resulting inflammatory skin disease that develops in mice lacking FGFR1 and FGFR2 in keratinocytes were further aggravated upon additional loss of FGFR3.
|
31830366 |
2020 |
Non-ST Elevated Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of our study was to assess the frequency of coronary microvascular spasm in patients with NSTEMI without culprit lesion (MINOCA) by intracoronary acetylcholine testing (ACH-test).
|
31236694 |
2020 |
Neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CAST‑PCR detected one FGFR3 mutation in 1/29 NBs.
|
31638167 |
2019 |
Pustulosis of Palms and Soles
|
0.010 |
Biomarker
|
disease |
BEFREE |
The disease, which often manifests with concurrent psoriasis vulgaris, can have an acute systemic (generalized pustular psoriasis [GPP]) or chronic localized (palmoplantar pustulosis [PPP] and acrodermatitis continua of Hallopeau [ACH]) presentation.
|
30036598 |
2019 |
Subarachnoid Hemorrhage
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FGFR3 siRNA worsened neurobehavioral function and suppressed the expression of PI3k, p-Akt, and Bcl-2 rather than FGFR1 siRNA in SAH rats treated with rFGF-2.
|
31203572 |
2019 |
Choroid Plexus Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
FGFR3 and FGFR1 proteins are expressed in a subpopulation of choroid plexus tumors.
|
31660579 |
2019 |
Cutaneous Melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FGFR3 expression in cutaneous malignant melanoma (CMM) tissues was positively correlated with the Breslow thickness and lymph node metastasis.
|
31619201 |
2019 |
Psoriasis vulgaris
|
0.010 |
Biomarker
|
disease |
BEFREE |
Psoriasis vulgaris concurrence was lowest in PPP (15.8% vs 54.4% in GPP and 46.2% in ACH, P < .0005 for both), whereas the mean age of onset was earliest in GPP (31.0 vs 43.7 years in PPP and 51.8 years in ACH, P < .0001 for both).
|
30036598 |
2019 |
Generalized pustular psoriasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The disease, which often manifests with concurrent psoriasis vulgaris, can have an acute systemic (generalized pustular psoriasis [GPP]) or chronic localized (palmoplantar pustulosis [PPP] and acrodermatitis continua of Hallopeau [ACH]) presentation.
|
30036598 |
2019 |
Acrodermatitis continua of Hallopeau
|
0.010 |
Biomarker
|
disease |
BEFREE |
The disease, which often manifests with concurrent psoriasis vulgaris, can have an acute systemic (generalized pustular psoriasis [GPP]) or chronic localized (palmoplantar pustulosis [PPP] and acrodermatitis continua of Hallopeau [ACH]) presentation.
|
30036598 |
2019 |
Oropharynx (excludes nasopharynx)
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
These results imply that the activity of the FGFR3 kinase in the infected epithelial cell restricts the HPV replication program through phosphorylation of E2 at Y138, which interferes with E2 binding to the Brd4 CTD, and that this interaction is required for initiation of viral DNA synthesis.<b>IMPORTANCE</b> Human papillomaviruses (HPVs) are highly infectious pathogens that commonly infect the oropharynx and uterine cervix.
|
30842331 |
2019 |
Progressive Neoplastic Disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Among patients with ACH, 25/28 (89.3%) had a complete response (CR), 2/28 (7.1%) had a partial response (PR) and 1/28 (3.6%) had a progressive disease (PD).
|
31074240 |
2019 |
Parathyroid Gland Adenocarcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Nine PC samples (47%) harbored at least one potentially actionable genomic alteration including in the after genes: ROS1 (5/19; 26%), PTEN (3/19; 16%), TSC1 (2/19; 11%), PIK3CA (1/19; 5%), AKT1 (1/19; 5%), MTOR (1/19; 5%), ERBB2 (1/19; 5%), NTRK1 (1/19; 5%), IDH1 (1/19; 5%) and FGFR3 (1/19; 5%).
|
30362515 |
2019 |
Central neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines.
|
31638167 |
2019 |
Small Fiber Neuropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Auto-antibodies targeting neuronal antigens trisulfated heparin disaccharide (TS-HDS) and fibroblast growth factor 3 (FGFR3) are found in up to 20% of patients with SFN.
|
31773305 |
2019 |
Progressive cGVHD
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among patients with ACH, 25/28 (89.3%) had a complete response (CR), 2/28 (7.1%) had a partial response (PR) and 1/28 (3.6%) had a progressive disease (PD).
|
31074240 |
2019 |
Childhood Neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines.
|
31638167 |
2019 |
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased cholinergic signalling in hippocampus also increases behaviours related to anxiety and depression in mice, which can be reversed by ACh receptor antagonists.
|
28264149 |
2018 |
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Increased cholinergic signalling in hippocampus also increases behaviours related to anxiety and depression in mice, which can be reversed by ACh receptor antagonists.
|
28264149 |
2018 |
Rheumatoid Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We further found that activated phospho-FGFR3 and -RSK2 were more highly observed in RA than in OA synovium.
|
29540697 |
2018 |