FGFR3, fibroblast growth factor receptor 3, 2261

N. diseases: 654; N. variants: 55
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 CausalMutation disease CGI
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 CausalMutation disease CLINVAR
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 AlteredExpression disease BEFREE 14.5% (16/110) of MM BM samples showed dysregulated FGFR3 expression. 12028033 2002
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 GeneticVariation disease BEFREE FGFR3 mutation analysis revealed no mutations in the presenting myeloma or MGUS samples. 12139740 2002
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease BEFREE FGFR3 is thus a plausible candidate for targeted therapy in a subset of MM patients. 15029211 2004
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 AlteredExpression disease BEFREE FGFR3 is expressed and is important for survival in INA-6, a human myeloma cell line without a t(4;14). 19594619 2009
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 PosttranslationalModification disease BEFREE Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer. 24466111 2014
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease BEFREE FGFR3 preferentially colocalizes with IGH in the interphase nucleus of multiple myeloma patient B-cells when FGFR3 is located outside of CT4. 27509849 2016
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 GeneticVariation disease BEFREE A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript. 12433679 2003
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 AlteredExpression disease LHGDN A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript. 12433679 2003
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease BEFREE A t(4;14)/IGH-FGFR3 was detected in 28 PCM (11.1%) and 5 MGUS (1.9%; P < 0.001). 21156229 2010
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 AlteredExpression disease BEFREE Although extensively studied in plasma cell neoplasms, there is little information in the literature regarding FGFR3 expression in malignant lymphomas, and it is unclear whether lymphoma patients may also benefit from anti-FGFR3 therapy. 18528286 2008
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 GeneticVariation disease BEFREE Among recurrent IGH translocations in MM, the frequency of t(4;14) (IGH and FGFR3) or t(11;14) (IGH and CCND1) is greater than the frequency of t(14;16) (IGH and MAF). 23460268 2013
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease BEFREE Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice. 19381019 2009
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 AlteredExpression disease BEFREE Approximately 15% of patients with multiple myeloma (MM) exhibit a t(4;14) translocation, which often results in constitutive activation of the receptor tyrosine kinase (RTK) fibroblast growth factor receptor 3 (FGFR3). 25402977 2015
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease BEFREE As a part of these translational efforts, novel drugs that inhibit oncogenic proteins overexpressed in defined molecular subgroups of the disease, such as FGFR3 and MMSET in t(4;14) MM, are currently being developed. 23233602 2012
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 AlteredExpression disease BEFREE As the expression of FGFR3 is undetectable in 30% of the t(4;14)+ MM patients, MMSET has been suggested to play an important role in the malignant transformation associated with the t(4;14) translocation. 16115125 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease BEFREE Bortezomib, dexamethasone, and fibroblast growth factor receptor 3-specific tyrosine kinase inhibitor in t(4;14) myeloma. 19147757 2009
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease BEFREE Chromosomal translocation of FGFR1 occurs in the 8p11 myeloproliferative syndrome and alveolar rhabdomyosarcoma, as with FGFR3 in multiple myeloma and peripheral T-cell lymphoma. 23696246 2014
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease CTD_human Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. 21936542 2011
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease BEFREE Expression of fibroblast growth factor receptor 3 (FGFR3), presumptively dysregulated on der(14), was detected by RT-PCR in only 23 of 31 (74%) patients with t(4;14)(+) MM. 12393535 2003
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease BEFREE Finally, using a mouse model of FGFR3 myeloma, we demonstrate a delay in tumor progression and prolonged survival of mice treated with PD173074. 14715624 2004
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 Biomarker disease BEFREE Findings from multiple myeloma (MM) indicate that FGFR3 also can act as an oncogene, and mutation of codon 249 in the fibroblast growth factor receptor 3 (FGFR3) gene was recently detected in 3/12 primary cervical carcinomas. 11904459 2001
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 GeneticVariation disease BEFREE Frequent FGFR3 kinase activating mutations in MM with t(4;14) translocations substantiate an oncogenic role for FGFR3. 9787135 1998
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.700 GeneticVariation disease BEFREE Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. 9207791 1997