Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 GeneticVariation disease BEFREE Histologically, both carcinomas were squamous cell carcinomas, therefore the incidence of the FGFR3 mutation among the squamous cell carcinoma cases was calculated as 3.2% (2/63). 24452392 2014
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 Biomarker disease BEFREE In addition, within the BRAF inhibitor-associated group, the lesions designated as KAs and BRAF inhibitor-associated verrucous keratoses had a similar mutational profile (mutations in PIK3CA, APC, and HRAS), which was distinct to that seen in squamous cell carcinomas (FGFR3, CDKN2A, and STK11). 26319365 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 Biomarker disease BEFREE The lung cancer subtypes share some genetic variations such as the dysfunction of tumor suppressor gene TP53, and also harbor specific variations of their own such as MET in ADC, FGFR1 and FGFR3 in SCC and MYC in SCLC. 27845189 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 Biomarker disease BEFREE We hypothesized that inhibiting FGFR3 would suppress tumor cell radioresistance and provide a new treatment approach for human SCCs. 21577207 2011
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 AlteredExpression disease BEFREE In contrast, the tyrosine kinase receptor FGF receptor-3 (FGFR3) and the transcription factor forkhead box N1 (FOXN1) were highly expressed in SKs, and close to undetectable in SCCs. 19729838 2009
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 GeneticVariation disease BEFREE Fibroblast growth factor receptor 3 S249C mutation in virus associated squamous cell carcinomas. 11605053 2001
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 GeneticVariation disease BEFREE We investigated the activation of FGFR3 and OIS by mutation and immunohistochemical analysis in skin tumours, including seborrhoeic keratosis, actinic keratosis (AK), Bowen's disease (BD), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). 19298285 2009
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 Biomarker disease BEFREE The FGFR3 gene was gained in 0.6% (1/179) of oral squamous cell carcinoma but no amplification was found in oral and oropharyngeal squamous cell carcinoma. 26711175 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 GeneticVariation disease BEFREE The S249C mutation in the FGFR3 gene was identified in one out of 101 SCCs (1%); the K600N, K660E, or R248C mutations were not identified. 29270870 2018