FGFR3, fibroblast growth factor receptor 3, 2261

N. diseases: 654; N. variants: 55
Disease: Multiple Myeloma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 Biomarker disease BEFREE Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice. 19381019 2009
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 AlteredExpression disease BEFREE FGFR3 is expressed and is important for survival in INA-6, a human myeloma cell line without a t(4;14). 19594619 2009
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 AlteredExpression disease BEFREE Although extensively studied in plasma cell neoplasms, there is little information in the literature regarding FGFR3 expression in malignant lymphomas, and it is unclear whether lymphoma patients may also benefit from anti-FGFR3 therapy. 18528286 2008
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 AlteredExpression disease BEFREE To detect FGFR3 protein expression, bone marrow (BM) aspirate from 200 consecutive newly diagnosed (n = 116) or relapsing (n = 74) MM patients was studied by flow cytometry (FC) using anti-CD138 and anti-FGFR3 antibodies. 17223917 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 GeneticVariation disease BEFREE In this study, the prognostic significance of morphology, CyclinD1 expression, proliferation index (Mib1) and presence of the translocations FGFR3/IgH [t(4;14)] and CCND1/IgH [t(11;14)] are compared in 119 patients with PM. 17460451 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 GeneticVariation disease BEFREE Simultaneous translocations of FGFR3/MMSET and CCND1 into two different IGH alleles in multiple myeloma: lack of concurrent activation of both proto-oncogenes. 17498561 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 GeneticVariation disease BEFREE Somatic FGFR3 mutations have been identified in several cancer entities such as urothelial carcinoma and multiple myeloma. 17172848 2006
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 Biomarker disease BEFREE To dissect the mechanism of FGFR3 oncogenesis in MM, we used 3 FGFR selective kinase inhibitors-CHIR258, PD173074, and SU5402-and FGFR3-specific siRNA to modulate FGFR3 activity. 16849642 2006
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 Biomarker disease BEFREE The data demonstrate that PRO-001 is a potent and specific inhibitor of FGFR3 and deserves further study for the treatment of FGFR3-expressing myeloma. 16467200 2006
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 AlteredExpression disease BEFREE Markedly increased MMSET expression was found in 1 MM showing associated FGFR3 and MMSET signals on an unidentified chromosome. 15543617 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 AlteredExpression disease BEFREE As the expression of FGFR3 is undetectable in 30% of the t(4;14)+ MM patients, MMSET has been suggested to play an important role in the malignant transformation associated with the t(4;14) translocation. 16115125 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 AlteredExpression disease BEFREE Three short hairpin RNAs (shRNA) targeting different sites of FGFR3 were selected and subsequently transfected into KMS-11, OPM-2, and NCI-H929 human myeloma cell lines, all of which are characterized by t(4;14) and FGFR3 over expression. 15897243 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 Biomarker disease LHGDN Ribozyme cleavage leads to decreased expression of fibroblast growth factor receptor 3 in human multiple myeloma cells, which is associated with apoptosis and downregulation of vascular endothelial growth factor. 15788896 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 Biomarker disease BEFREE Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in multiple myeloma. 15761022 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 GeneticVariation disease BEFREE The identification in multiple myeloma and in two epithelial cancers-bladder and cervical carcinomas-of somatic FGFR3 mutations identical to the germinal activating mutations found in skeletal dysplasias, together with functional studies, have suggested an oncogenic role for this receptor. 15772091 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 Biomarker disease BEFREE Nearly half of these tumors are nonhyperdiploid and mostly have immunoglobulin H (IgH) translocations that involve 5 recurrent chromosomal loci, including 11q13 (cyclin D1), 6p21 (cyclin D3), 4p16 (fibroblast growth factor receptor 3 [FGFR3] and multiple myeloma SET domain [MMSET]), 16q23 (c-maf), and 20q11 (mafB). 15090448 2004
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 Biomarker disease BEFREE Finally, using a mouse model of FGFR3 myeloma, we demonstrate a delay in tumor progression and prolonged survival of mice treated with PD173074. 14715624 2004
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 Biomarker disease BEFREE FGFR3 is thus a plausible candidate for targeted therapy in a subset of MM patients. 15029211 2004
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 PosttranslationalModification disease BEFREE SU5402 inhibited FGFR3 phosphorylation in vitro and in murine MM tumour models. 14871245 2004
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 GeneticVariation disease BEFREE The t(4;14)(p16;q32) translocation seen in c. 18% of newly diagnosed multiple myeloma (MM) cases, results in FGFR3 activation and creation of an IGH/MMSET fusion transcript. 15198734 2004
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 AlteredExpression disease BEFREE Overexpression of the myeloma-associated oncogene FGFR3, which upregulates bcl-x(L), delayed but did not prevent caspase-3-mediated killing. 12907145 2003
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 GeneticVariation disease BEFREE A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript. 12433679 2003
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 Biomarker disease BEFREE Expression of fibroblast growth factor receptor 3 (FGFR3), presumptively dysregulated on der(14), was detected by RT-PCR in only 23 of 31 (74%) patients with t(4;14)(+) MM. 12393535 2003
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 GeneticVariation disease BEFREE Nearly 40% of MM tumors have immunoglobulin H (IgH) translocations involving four recurrent chromosomal loci (oncogenes): 11q13 (cyclin D1), 6p21 (cyclin D3), 4p16 (MMSET and FGFR3), and 16q23 (c-maf). 12846810 2003
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.700 AlteredExpression disease LHGDN A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript. 12433679 2003