Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.070 GeneticVariation disease BEFREE In squamous cell carcinoma (SCC) of the lung, mutations within the genes of fibroblast growth factor receptors (FGFR) such as K660N/K660E in FGFR2 and R248C/S249C in FGFR3 and FGFR1 gene amplification have been described, but their prognostic relevance still remains unclear. 29270870 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.070 Biomarker disease BEFREE The FGFR3 gene was gained in 0.6% (1/179) of oral squamous cell carcinoma but no amplification was found in oral and oropharyngeal squamous cell carcinoma. 26711175 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.070 Biomarker disease BEFREE Fibroblast Growth Factor (FGF-2) and Its Receptors FGFR-2 and FGFR-3 May Be Putative Biomarkers of Malignant Transformation of Potentially Malignant Oral Lesions into Oral Squamous Cell Carcinoma. 26465941 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.070 Biomarker disease BEFREE In addition, within the BRAF inhibitor-associated group, the lesions designated as KAs and BRAF inhibitor-associated verrucous keratoses had a similar mutational profile (mutations in PIK3CA, APC, and HRAS), which was distinct to that seen in squamous cell carcinomas (FGFR3, CDKN2A, and STK11). 26319365 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.070 Biomarker disease BEFREE Our results provided novel information on which to base further mechanistic study of radiosensitization by inhibiting FGFR3 in human SCC cells and for developing strategies to improve outcomes with concurrent radiotherapy. 21577207 2012
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.070 AlteredExpression disease BEFREE In contrast, the tyrosine kinase receptor FGF receptor-3 (FGFR3) and the transcription factor forkhead box N1 (FOXN1) were highly expressed in SKs, and close to undetectable in SCCs. 19729838 2010
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.070 GeneticVariation disease BEFREE We investigated the activation of FGFR3 and OIS by mutation and immunohistochemical analysis in skin tumours, including seborrhoeic keratosis, actinic keratosis (AK), Bowen's disease (BD), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). 19298285 2009