Seborrheic keratosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Additional research is needed to further establish possible etiological risk factors and to clarify the involvement of PIK3CA and FGFR3 genes in the pathogenesis of seborrheic keratosis of the outer ear canal.
|
29485181 |
2018 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We reviewed the literature concerning genetic FGFR3 alterations in seborrhoeic keratosis.
|
28627087 |
2017 |
Seborrheic keratosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, mutational analysis from each tumor indicates that the overlapping SK and SCC evolved independently and supports our conclusion that FGFR3 activation is insufficient to drive SCC.
|
24626198 |
2014 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
FGFR3, PIK3CA and RAS mutations have been shown to be involved in the pathogenesis of seborrhoeic keratosis and solar lentigo.
|
22188534 |
2012 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Because FGFR3 and PIK3CA mutations have been reported to be involved in the pathogenesis of seborrhoeic keratosis, we analysed whether these mutations are also present in STK and DPN.
|
19845664 |
2010 |
Seborrheic keratosis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In contrast, the tyrosine kinase receptor FGF receptor-3 (FGFR3) and the transcription factor forkhead box N1 (FOXN1) were highly expressed in SKs, and close to undetectable in SCCs.
|
19729838 |
2009 |
Seborrheic keratosis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The activation of FGFR3 might be a common feature in the tumorigenesis in seborrhoeic keratosis, although the activation does not induce a typical oncogenic signal in keratinocytes.
|
19298285 |
2009 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Somatic oncogenic activating mutations in FGFR3 and/or PIK3CA have recently been described in benign epithelial cutaneous lesions that never progress to malignancy (seborrheic keratoses and epidermal nevi).
|
18728396 |
2008 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
One SK with a FGFR3 mutation additionally showed a hotspot PIK3CA mutation.
|
18503601 |
2008 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
One SK with a FGFR3 mutation additionally showed a hotspot PIK3CA mutation.
|
18503601 |
2008 |
Seborrheic keratosis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Ki-67 expression was significantly higher in seborrheic keratoses than in normal epidermis independent of the FGFR3 status (P<0.001).
|
17585316 |
2007 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we examined exons 9 and 20 of PIK3CA and FGFR3 hotspot mutations in EN (n = 33) and SK (n = 62), two proliferative skin lesions lacking malignant potential.
|
17673550 |
2007 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin.
|
17568799 |
2007 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots.
|
17392824 |
2007 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Based on the occurrence of fibroblast growth factor receptor 3 (FGFR3) mutations in seborrheic keratosis and urothelial carcinomas (UC), and the identification of two young patients with EN and UC, we hypothesized that mutations might occur in EN.
|
17255960 |
2007 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Ki-67 expression was significantly higher in seborrheic keratoses than in normal epidermis independent of the FGFR3 status (P<0.001).
|
17585316 |
2007 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots.
|
17392824 |
2007 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Adenoid SKs seem to be characterized by a higher frequency of FGFR3 mutations than hyperkeratotic and acanthotic SKs.
|
16778799 |
2006 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Adenoid SKs seem to be characterized by a higher frequency of FGFR3 mutations than hyperkeratotic and acanthotic SKs.
|
16778799 |
2006 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, the same FGFR3 mutations known from skeletal dysplasia syndromes and urothelial carcinoma have been shown to cause benign human skin tumors such as seborrheic keratoses and epidermal nevi.
|
17172848 |
2006 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We therefore screened a series of 62 cases of seborrheic keratosis for FGFR3 mutations.
|
15772091 |
2005 |
Seborrheic keratosis
|
0.500 |
GeneticVariation
|
disease |
UNIPROT |
We therefore screened a series of 62 cases of seborrheic keratosis for FGFR3 mutations.
|
15772091 |
2005 |
Seborrheic keratosis
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
|
|
|