Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.
|
1851551 |
1991 |
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We conclude that tissue levels of FGFR2 mRNA are unaltered in breast cancer extracts and that the splicing mechanism for this exon selection appears not to be significantly disrupted.
|
8814701 |
1996 |
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The level of FGFR-2-IIIb present on breast cancer cell lines was sufficient for KGF stimulation of breast cancer cell proliferation.
|
9184170 |
1997 |
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
One-third of these loci affected breast cancer oncogenes, whose amplifications were validated with specific probes: 17q12 (two cell lines with ERBB2 amplifications), 11q13 (two with cyclin-D1), 8p11-p12 (two with FGFR1) and 10q25 (one with FGFR2).
|
10604729 |
1999 |
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
A breast cancer cell line developed in our laboratory, SUM-52PE, was shown to have a 12-fold amplification of the FGFR2 gene, and FGFR2 message was found to be overexpressed 40-fold in SUM-52PE cells as compared with normal human mammary epithelial (HME) cells.
|
11056689 |
2000 |
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, three consecutive microarray (CGH, cDNA and tissue) experiments revealed high-level amplification and overexpression of the FGFR2 in a breast cancer cell line, but only a low frequency of involvement in primary breast tumors.
|
11564899 |
2001 |
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
A breast cancer cell line developed in our laboratory (SUM-52PE) has a 12-fold amplification and high-level overexpression of the oncogene fibroblast growth factor receptor 2 (FGFR2).
|
15561780 |
2004 |
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
TC-1 was down regulated by the FGFR inhibitor PD173074 in the breast cancer cell line SUM-52 that also has an FGFR2 gene amplification and over expression.
|
17520678 |
2007 |
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Gene amplification and protein overexpression of fibroblast growth factor receptor 2 (FGFR2) characterize the SUM-52 breast cancer cell line developed in our laboratory.
|
17133345 |
2007 |
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies novel breast cancer susceptibility loci.
|
17529967 |
2007 |
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
CTD_human |
We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer and confirmed this association in 1,776 affected individuals and 2,072 controls from three additional studies.
|
17529973 |
2007 |
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer and confirmed this association in 1,776 affected individuals and 2,072 controls from three additional studies.
|
17529973 |
2007 |
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies novel breast cancer susceptibility loci.
|
17529967 |
2007 |
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We also noted a correlation between the number of minor alleles of rs2981582 in FGFR2 and the average number of first-degree and second-degree relatives with breast cancer and/or ovarian cancer (P = 0.05).
|
17997823 |
2007 |
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer and confirmed this association in 1,776 affected individuals and 2,072 controls from three additional studies.
|
17529973 |
2007 |
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
We stably overexpressed the FN target, MAGE A3, which has also been identified as a target of the breast cancer risk factor fibroblast growth factor receptor 2, and examined the functional effects in vitro and in vivo in a flank model and an orthotopic model of thyroid cancer.
|
18829569 |
2008 |
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
BEFREE |
Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.
|
18462018 |
2008 |
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) of FGFR2 are associated with increased risk of breast cancer.
|
18636142 |
2008 |
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We obtained a significant allele P value of association with AJ breast cancer in the FGFR2 region (P = 1.5 x 10(-5), odds ratio (OR) 1.26, 95% confidence interval (CI) 1.13-1.40 at rs1078806 for all phases combined).
|
18326623 |
2008 |
Malignant neoplasm of breast
|
0.700 |
Biomarker
|
disease |
CTD_human |
Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer.
|
18438407 |
2008 |
Malignant neoplasm of breast
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Small interfering RNA was transfected into a human keratinocyte cell line (HaCaT), a breast cancer derived cell line (MCF-7) and a keratinocyte primary culture (KCs) to induce selective downregulation of KGFR expression.
|
18575591 |
2008 |
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 13 single nucleotide polymorphisms (SNPs) densely covering a 27 kb region within intron 2 of FGFR2 including two SNPs (rs2981582 and rs1219648) significantly associated with breast cancer and a total 40 tagSNPs across 150 kb of the FGFR2 gene.
|
18285324 |
2008 |
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the present study of 1049 breast cancer patients and 1073 cancer-free controls, we assessed whether polymorphisms of FGFR2 are associated with breast cancer risk in Chinese women and whether these associations are stronger in women with a reproductive history suggestive of greater exposure to endogenous estrogens.
|
18845558 |
2008 |
Malignant neoplasm of breast
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific protein 1 (LSP1)) associated with breast cancer risk.
|
18437204 |
2008 |