FGFR2, fibroblast growth factor receptor 2, 2263

N. diseases: 731; N. variants: 141
Disease: Thyroid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.050 Biomarker disease BEFREE We stably overexpressed the FN target, MAGE A3, which has also been identified as a target of the breast cancer risk factor fibroblast growth factor receptor 2, and examined the functional effects in vitro and in vivo in a flank model and an orthotopic model of thyroid cancer. 18829569 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.050 Biomarker disease BEFREE Furthermore, we suggest the potential use of FGFR-2 as an early marker for thyroid cancer diagnosis. 23977259 2013
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.050 Biomarker disease BEFREE More specifically, they show how alternative splicing of FGFR2 yields heteroisoforms critical to the growth-promoting actions of FGFs that exert distinct epithelial-stromal effects in thyroid cancer. 22345151 2012
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.050 PosttranslationalModification disease BEFREE We reported recently that FGF receptor 2 (FGFR2) is down-regulated through extensive DNA promoter methylation in thyroid cancer. 17699848 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.050 AlteredExpression disease BEFREE In addition, SC-101 mAb was able to detect KGFR down-modulation in thyroid cancer. 24899248 2014