FGFR2, fibroblast growth factor receptor 2, 2263

N. diseases: 731; N. variants: 141
Disease: Endometrial Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.700 GeneticVariation disease BEFREE We tested the cytotoxicity of AL3818 on a panel of 7 human endometrial cancer cell lines expressing either wild-type or mutant FGFR2 and also assessed the in vivo antitumor efficacy in a murine, orthotopic AN3CA endometrial cancer model. 28953502 2018
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.700 Biomarker disease BEFREE Of 248 patients with FGFR2 prescreening results, 27 (11%) had FGFR2(mut) endometrial cancer. 25981814 2015
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.700 CausalMutation disease CLINVAR
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.700 Biomarker disease CTD_human Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. 21936542 2011
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.700 CausalMutation disease CGI