FGFR2, fibroblast growth factor receptor 2, 2263

N. diseases: 731; N. variants: 141
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.070 GeneticVariation disease BEFREE Truncated forms of FGFR2 lacking the C-terminal tail, including S780, have been identified in cancer and S780 has been found mutated to leucine in bladder cancer. 31146385 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.070 Biomarker disease BEFREE Taken together, silencing circular RNA UVRAG inhibited bladder cancer growth and metastasis by targeting the miR-223/FGFR2 axis, which may provide a potential biomarker and therapeutic target for the management of BLCA. 30387298 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.070 AlteredExpression disease BEFREE Our findings are consistent with the results of the TCGA data set for the "squamous-like" subtype of bladder cancer (n = 85), which revealed reduced overall expression of FGFR1 and FGFR2 in tumors compared to normal tissue, while expression of FGFR3 remained high. 27669755 2016
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.070 GeneticVariation disease BEFREE To further evaluate the importance of FGFR2 exon 7 alterations in bladder cancer a cohort of 254 bladder tumors (cohort 1: unselected cases: n=139; cohort 2: early-onset bladder cancer cases (age at time of diagnosis≤45 years): n=115) was analyzed. 24817968 2014
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.070 Biomarker disease BEFREE In addition, several FGFRs are mutated in human cancers (including FGFR2 in gastric cancer and FGFR3 in bladder cancer). 17697126 2007
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.070 Biomarker disease BEFREE Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. 17145872 2006
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.070 Biomarker disease BEFREE Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer. 10602477 1999