FGFR2, fibroblast growth factor receptor 2, 2263

N. diseases: 665; N. variants: 90
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.620 Biomarker group CTD_human Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. 21936542 2012
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.620 Biomarker group CTD_human Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy. 21173787 2012
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.620 AlteredExpression group LHGDN Results reveal that both the FGFR2 and EGFR family signaling pathways are activated in FGFR2-amplified gastric cancer cell lines to drive cell proliferation and survival. 18381441 2008
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.620 PosttranslationalModification group LHGDN Thus, our results suggest that the epigenetic silencing of FGFR2 through DNA methylation in gastric cancer may contribute to tumor progression. 17459342 2007
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.620 CausalMutation group CLINVAR Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. 11325814 2001
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.620 CausalMutation group CLINVAR Analysis of the mutational spectrum of the FGFR2 gene in Pfeiffer syndrome. 10394936 1999
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.620 CausalMutation group CGI
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.620 GenomicAlterations group CGI