Cholangiocarcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor receptor 2 (FGFR2) might have an important role in the pathogenesis and biology of cholangiocarcinoma (CCA).
|
31351075 |
2019 |
Cholangiocarcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Herein, we report the first case with cholangiocarcinoma harboring <i>FGFR2-BICC1</i> who is sensitive to sorafenib therapy.
|
31807010 |
2019 |
Cholangiocarcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The current review comprehensively focuses on the role of FGFR2 inhibition either alone or in combination with other targeted therapy that act on down-stream and alternate kinase pathways in cholangiocarcinoma.
|
31255945 |
2019 |
Cholangiocarcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
HSP90 Inhibition Drives Degradation of FGFR2 Fusion Proteins: Implications for Treatment of Cholangiocarcinoma.
|
30067876 |
2019 |
Cholangiocarcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For example, IDH catalytic site mutations and constitutively active FGFR2 fusion genes are predominantly identified in iCCA, whereas KRAS mutations and PRKACB fusions genes are identified in pCCA and dCCA.
|
28844952 |
2018 |
Cholangiocarcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Methods A multicenter, open-label, phase II study ( ClinicalTrials.gov identifier: NCT02150967) evaluated BGJ398 antitumor activity in patients age ≥ 18 years with advanced or metastatic cholangiocarcinoma containing FGFR2 fusions or other FGFR alterations whose disease had progressed while receiving prior therapy.
|
29182496 |
2018 |
Cholangiocarcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Polyclonal Secondary <i>FGFR2</i> Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.
|
28034880 |
2017 |
Cholangiocarcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using this PDX model, we confirmed the ability of the FGFR inhibitors, ponatinib, dovitinib and BGJ398, to modulate FGFR signaling, inhibit cell proliferation and induce cell apoptosis in cholangiocarcinoma tumors harboring FGFR2 fusions.
|
27216979 |
2016 |
Cholangiocarcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genomic spectra of biliary tract cancer.
|
26258846 |
2015 |
Cholangiocarcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma.
|
25763789 |
2015 |
Cholangiocarcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Histologically, cholangiocarcinomas with FGFR2 translocations displayed prominent intraductal growth (62%) or anastomosing tubular glands with desmoplasia (38%).
|
24837095 |
2014 |
Cholangiocarcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Through a prospective clinical sequencing program for advanced cancers, four index cases were identified which harbor gene rearrangements of FGFR2, including patients with cholangiocarcinoma, breast cancer, and prostate cancer.
|
23558953 |
2013 |