FGFR2, fibroblast growth factor receptor 2, 2263

N. diseases: 731; N. variants: 141
Disease: endometrial adenoacanthoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0279763
Disease: endometrial adenoacanthoma
endometrial adenoacanthoma 		0.100 GeneticVariation disease CLINVAR The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors. 23908597 2013
CUI: C0279763
Disease: endometrial adenoacanthoma
endometrial adenoacanthoma 		0.100 GeneticVariation disease CLINVAR Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models. 22238366 2012
CUI: C0279763
Disease: endometrial adenoacanthoma
endometrial adenoacanthoma 		0.100 GeneticVariation disease CLINVAR FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor. 23002168 2012
CUI: C0279763
Disease: endometrial adenoacanthoma
endometrial adenoacanthoma 		0.100 GeneticVariation disease CLINVAR Drug-sensitive FGFR2 mutations in endometrial carcinoma. 18552176 2008