|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This refinement of the association between FGFR2 variants and ER-status to HER2-negative disease provides novel insight to potential biological and clinical influence of genetic polymorphisms on breast tumors.
|
27764800 |
2016 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Moreover, the increased risk conferred by the minor FGFR2 allele associates most strongly in oestrogen receptor alpha positive (ERα) breast tumours, suggesting a potential interaction between ERα and FGFR signalling.
|
24265722 |
2013 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
FGFR2 and FGF10, the main ligand of FGFR2, are both overexpressed in 5-10% of breast tumors.
|
23527311 |
2013 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
In a population-based case-control study of 1,170 breast cancer cases and 2,115 controls, we examined genetic associations of four intronic FGFR2 single-nucleotide polymorphisms (SNPs) and breast tumor characteristics and assessed the potential interactions with smoking, alcohol consumption, adiposity and known breast cancer risk factors.
|
20853316 |
2011 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
In 25 breast tumors, no associations between breast tumor characteristics and fibroblast FGFR2 mRNA levels were found.
|
21767389 |
2011 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
LHGDN |
We examined FGFR2 and MAP3K1 variants, breast tumor characteristics and hormone exposures in a population-based case-control sample of 1225 European-American (EA) and 584 African-American (AA) women.
|
19028704 |
2009 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
LHGDN |
FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations.
|
18483326 |
2008 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women.
|
18845558 |
2008 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer.
|
18438407 |
2008 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
|
18355772 |
2008 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis.
|
18767044 |
2008 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.
|
17529973 |
2007 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.
|
17997823 |
2007 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.
|
17529973 |
2007 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
Genome-wide association study identifies novel breast cancer susceptibility loci.
|
17529967 |
2007 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells.
|
17133345 |
2007 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
Transforming potential of alternatively spliced variants of fibroblast growth factor receptor 2 in human mammary epithelial cells.
|
15561780 |
2004 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
In conclusion, three consecutive microarray (CGH, cDNA and tissue) experiments revealed high-level amplification and overexpression of the FGFR2 in a breast cancer cell line, but only a low frequency of involvement in primary breast tumors.
|
11564899 |
2001 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
For two of these regions, 8p12 and 10q26, we previously reported the amplification of genes encoding FGF receptors, FGFRI/FLG and FGFR2/BEK, in about 12% of breast tumors.
|
7692948 |
1993 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
BEK and FLG were found amplified in 11.5 and 12.7% of breast tumors respectively.
|
1851551 |
1991 |