FGFR2, fibroblast growth factor receptor 2, 2263

N. diseases: 731; N. variants: 141
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 GeneticVariation disease BEFREE Analyses of genetic alterations have identified those that might be targeted therapeutically, such as fusions in the FGFR2 gene and mutations in genes encoding isocitrate dehydrogenases (in approximately 60% of iCCAs) or amplifications at 11q13 and 6p21 (in approximately 15% of HCCs). 28043904 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 GeneticVariation disease BEFREE Screening of a cohort of 107 iCCA patients reveals that FGFR2 fusions represent the most recurrent targetable alteration (45%, 17/107), while they are rarely present in other primary liver tumours (0/100 of hepatocellular carcinoma (HCC); 1/21 of mixed iCCA-HCC). 25608663 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 AlteredExpression disease BEFREE Inhibition of FGFR2 phosphorylation in HCC abolished FGF1-stimulated MMP7 and MMP26 expression, suggesting that activation of the FGFR signaling pathway in HCC may promote cancer metastasis by inducing MMP7 and MMP26 expression. 25091573 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 AlteredExpression disease BEFREE FGFR2-IIIb re-expression in stable transfected HCC cell lines induced a higher basal apoptosis rate and a significantly reduced proliferation and migratory potential in vitro. 20093481 2010
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 AlteredExpression disease BEFREE Fgfr2 was 4.7 times up-regulated in poorly differentiated HCC from a nodule-in-nodule sample. 20798558 2010