Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
FISH with FHIT gene probe revealed deletions in cRCC (88%), breast (30%), and lung tumors (10%).
|
21962529 |
2013 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
As TRAIL represents in the near future a good candidate for death ligands-based anticancer therapy, its potential therapeutic use should be envisaged as preliminary to molecular genetics interventions or drug-induced epigenetic modulations aimed to restoring FHIT gene expression levels in non-small cells lung tumors.
|
19418484 |
2009 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sixty-two patients with suspected lung tumors were screened for variations within exons 5-9 of the FHIT gene using intronic primer pairs and single-strand conformation polymorphism and sequencing analysis.
|
19267103 |
2009 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to investigate the different molecular alterations leading to the inactivation of FHIT gene function and to validate their use as biomarkers of risk for progression of the disease in patients belonging to the multicentric European study for the Early detection of Lung Cancer (EUELC) who were resected for early-stage lung tumors.
|
19096006 |
2009 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
FHIT and p53 status and response to platinum-based treatment in advanced non-small cell lung cancer.
|
18690840 |
2008 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.
|
17328863 |
2007 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To further explore the molecular mechanisms between altered TSGs promoter methylation and overexpression of DNMTs protein, we performed a tissue chromatin-immunoprecipitation polymerase chain reaction assay for lung tumors and showed that the methylated FHIT, p16(INK4a) and RARbeta promoters were bound by both DNMT protein and methyl-CpG-binding protein 2.
|
17140695 |
2007 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There was concordance of HYAL2 or FHIT deletions in matched sputum and tumor tissues from lung cancer patients (r = 0.82, P = 0.04; r = 0.84, P = 0.03), suggesting that the genetic changes in sputum might indicate the presence of the same genetic aberrations in lung tumors.
|
17255269 |
2007 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Microsatellite analysis of induced sputum DNA in patients with lung cancer in heavy smokers and in healthy subjects.
|
17694439 |
2007 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
FHIT protein enhances paclitaxel-induced apoptosis in lung cancer cells.
|
16231322 |
2006 |
Lung Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Loss of fragile histidine triad gene expression in advanced lung cancer is consequent to allelic loss at 3p14 locus and promoter methylation.
|
16513840 |
2006 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Frequent FHIT gene loss of heterozygosity in human papillomavirus-infected non-smoking female lung cancer in Taiwan.
|
15935551 |
2006 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency.
|
16061637 |
2005 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis.
|
12169206 |
2003 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
[Effects of ectogenous FHIT gene on reversing malignant phenotype of human lung adenocarcinoma cells A549].
|
12048684 |
2002 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients.
|
11788890 |
2002 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
This idea is supported by the more recent finding that FRA3B maps within the FHIT (fragile histadine triad) gene, and that aberrant transcripts and genomic deletions of FHIT/FRA3B occur in a variety of tumors including lung tumors.
|
12007194 |
2002 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
When treated with DOTAP:Chol-p53 and -FHIT complex, significant suppression was observed in both primary (P < 0.02) and metastatic lung tumor growth (P < 0.007).
|
11273776 |
2001 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers.
|
10959838 |
2001 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We screened 40 primary lung tumors for the presence of point mutations within the coding exons of FHIT using PCR-single-strand conformational polymorphism.
|
9581816 |
1998 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus.
|
9662254 |
1998 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Abnormalities in structure and expression of the FHIT gene have been detected in a considerable fraction of primary lung tumors.
|
9850082 |
1998 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Using specific antibodies against the Fhit protein, we observed concordance between RNA abnormalities and lack of Fhit protein expression in lung tumors and cell lines.
|
9393735 |
1997 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To identify genetic lesions characteristic of tobacco damage, we undertook a molecular analysis of microsatellite alterations within the FHIT gene and FRA3B, as well as at an independent locus on chromosome 10, D10S197, in lung tumors from heavy smokers and in tumors from never smokers.
|
9187107 |
1997 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Small cell lung tumors (80%) and non-small cell lung cancers (40%) showed abnormalities in RNA transcripts of FHIT, and 76% of the tumors exhibited loss of FHIT alleles.
|
8620533 |
1996 |