|
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSIONS The methylation of p16 and FHIT genes was an independent risk factor for hepatocellular carcinoma.
|
30773529 |
2019 |
|
Liver carcinoma
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, BLU methylation was associated with an increased level of alpha-fetoprotein, and FHIT methylation was inversely correlated with HCC recurrence.
|
22766745 |
2013 |
|
Liver carcinoma
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, we investigated the influence of DNA methyltransferase 3b (DNMT3b) on fragile histidine trial (FHIT) expression and on DNA methylation of the FHIT promoter region in the hepatoma cell line SMMC-7721.
|
19502167 |
2009 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of FHIT protein (Fhit) was observed in 8 (16.7%) of 48 HCC samples, with complete loss of Fhit in only 1 case.
|
18567082 |
2008 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Reduced expression of FHIT protein (Fhit) was observed in 8 (16.7%) of 48 HCC samples, with complete loss of Fhit in only 1 case.
|
18567082 |
2008 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
LHGDN |
A recombinant pcDNA3.1 (+)/FHIT including the functional region of FHIT gene was constructed and transferred into human hepatocellular carcinoma cells in vitro. mRNA and protein expression of the FHIT gene in the transfected cells was detected by RT-PCR and Western blot, respectively.
|
18595145 |
2008 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
A recombinant pcDNA3.1 (+)/FHIT including the functional region of FHIT gene was constructed and transferred into human hepatocellular carcinoma cells in vitro. mRNA and protein expression of the FHIT gene in the transfected cells was detected by RT-PCR and Western blot, respectively.
|
18595145 |
2008 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To evaluate the expression of fragile histidine triad (FHIT) gene protein, product of a candidate tumor suppressor, and to investigate the relationship between FHIT, cell apoptosis and proliferation, and pathological features of primary hepatocellular carcinoma (HCC).
|
15633221 |
2005 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The results of the present study indicate that the FHIT gene is a frequent target in hepatitis C virus-associated HCC and that alterations affecting this gene could be an early event in this type of neoplasm as they were detected in cirrhotic and CAH patients.
|
15610452 |
2005 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
LHGDN |
To evaluate the expression of fragile histidine triad (FHIT) gene protein, product of a candidate tumor suppressor, and to investigate the relationship between FHIT, cell apoptosis and proliferation, and pathological features of primary hepatocellular carcinoma (HCC).
|
15633221 |
2005 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Loss of fragile histidine triad (FHIT) gene expression is seen in approximately 50% of hepatocellular carcinomas in China.
|
15060557 |
2004 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Loss of fragile histidine triad (FHIT) gene expression is seen in approximately 50% of hepatocellular carcinomas in China.
|
15060557 |
2004 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Loss of fragile histidine triad protein in human hepatocellular carcinoma.
|
12800227 |
2003 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
RGD |
These results indicated that changes in the Fhit gene occur frequently and may thus play some role in the development of HCCs induced by DEN in rats.
|
12112319 |
2002 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The FHIT gene is expressed in normal hepatic cells and is not expressed or is abnormally expressed in cultured tumor cells derived from HCC.
|
10706123 |
2000 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Different gene expression of MDM2, GAGE-1, -2 and FHIT in hepatocellular carcinoma and focal nodular hyperplasia.
|
10389981 |
1999 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To determine whether transcriptional alterations of the fragile histidine triad (FHIT) gene play a role in the development and progression of human hepatocellular carcinoma (HCC) we used reverse transcription-PCR to examine mRNA FHIT expression in 28 paired samples of HCC (24 in cirrhotic and 4 in noncirrhotic livers) and matched noncancerous tissue and in 10 normal livers.
|
10589760 |
1999 |
|
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Although five out of eight liver cancer cell lines (62.5%), 12 out of 18 HCC tissues (66.7%) and 8 out of 18 paired non-tumorous liver tissues (44.4%) displayed abnormal faint bands of smaller size, sequence analysis revealed that they were aberrant FHIT transcripts lacking three or more exons and might represent alternatively spliced transcripts only.
|
9472637 |
1998 |