|
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
|
30787307 |
2019 |
|
Asthma
|
0.460 |
Biomarker
|
disease |
BEFREE |
To investigate whether the genetic variants of TGFB1, TLE4, MUC22 and IKZF3 are associated with the development of asthma in Chinese children.
|
28262390 |
2018 |
|
Asthma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal region 17q12-q21 is associated with asthma and harbors regulatory polymorphisms that influence expression levels of all five protein-coding genes in the region: IKAROS family zinc finger 3 (Aiolos) (IKZF3), zona pellucida binding protein 2 (ZPBP2), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and gasdermins A and B (GSDMA, GSDMB).
|
28241063 |
2017 |
|
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
A meta-analysis of genome-wide association studies of asthma in Puerto Ricans.
|
28461288 |
2017 |
|
Asthma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
In the Swedish Search study, we found significant differences in DNA methylation between asthmatics and controls in five CpG sites; after adjusting for lymphocyte and neutrophil cell counts, three remained significant: one in IKZF3 [IKAROS family zinc finger 3 (Aiolos); cg16293631] and two in the CpG island (CGI) of ORMDL3 (cg02305874 and cg16638648).
|
25256354 |
2015 |
|
Asthma
|
0.460 |
Biomarker
|
disease |
CTD_human |
In the Swedish Search study, we found significant differences in DNA methylation between asthmatics and controls in five CpG sites; after adjusting for lymphocyte and neutrophil cell counts, three remained significant: one in IKZF3 [IKAROS family zinc finger 3 (Aiolos); cg16293631] and two in the CpG island (CGI) of ORMDL3 (cg02305874 and cg16638648).
|
25256354 |
2015 |
|
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
|
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study.
|
24406073 |
2014 |
|
Asthma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the strong allelic association between SNPs in the 17q21 region and asthma in Latinos (IKZF3, lowest P value: rs90792, odds ratio, 0.67; 95% CI, 0.61-0.75; P = 6 × 10(-13)) and replicated associations in several genes that had previously been associated with asthma in genome-wide association studies.
|
24406073 |
2014 |
|
Asthma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
We found 2 SNPs (1 novel rs9635726 in IKZF3) to be associated with asthma.
|
23622005 |
2013 |
|
Asthma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Sixteen SNPs were significantly associated with asthma after multiple testing correction (P ≤ .01), of which 5 (rs2290400, rs8079416, rs3894194, rs7212938, and rs3859192) were strongly associated (FDR P ≤ .0002), and one was novel (IKZF3-rs1453559).
|
22626592 |
2012 |
|
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.330 |
GeneticVariation
|
disease |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
|
Chronic Lymphocytic Leukemia
|
0.330 |
Biomarker
|
disease |
BEFREE |
We show that non-coding mutations in ATM may negatively impact on ATM expression and find non-coding and regulatory region mutations in TCL1A, and in IgHV<sup>unmut</sup> CLL in IKZF3, SAMHD1,PAX5 and BIRC3.
|
28584254 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
<i>IKZF1</i> and <i>IKZF3 (</i>encoding transcription factors Ikaros and Aiolos) are susceptibility loci for systemic lupus erythematosus (SLE).
|
29945920 |
2018 |
|
Chronic Lymphocytic Leukemia
|
0.330 |
SomaticCausalMutation
|
disease |
ORPHANET |
These include previously unrecognized putative cancer drivers (RPS15, IKZF3), and collectively identify RNA processing and export, MYC activity, and MAPK signalling as central pathways involved in CLL.
|
26466571 |
2015 |
|
Chronic Lymphocytic Leukemia
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
These include previously unrecognized putative cancer drivers (RPS15, IKZF3), and collectively identify RNA processing and export, MYC activity, and MAPK signalling as central pathways involved in CLL.
|
26466571 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.330 |
GeneticVariation
|
disease |
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IKZF3 and SLE in the Chinese Han population.
|
25271777 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study.
|
22464253 |
2012 |
|
Chronic Lymphocytic Leukemia
|
0.330 |
PosttranslationalModification
|
disease |
BEFREE |
The chromatin status at the Aiolos promoter in CLL is defined by the demethylation of DNA and an enrichment of euchromatin associated histone markers, such as the dimethylation of the lysine 4 on histone H3.
|
21139082 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.330 |
Biomarker
|
disease |
MGD |
Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice.
|
12574333 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.330 |
Biomarker
|
disease |
MGD |
Aiolos regulates B cell activation and maturation to effector state.
|
9806640 |
1998 |
|
Rheumatoid Arthritis
|
0.320 |
Biomarker
|
disease |
BEFREE |
In addition, IL6R, BACH2, RASGRP1, TLE3, and IKZF3 are replicated for the first time in an independent European population and IL6 appears to be a suggestive new RA associated locus.
|
26939566 |
2016 |