Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
|
30787307 |
2019 |
Asthma
|
0.460 |
Biomarker
|
disease |
BEFREE |
To investigate whether the genetic variants of TGFB1, TLE4, MUC22 and IKZF3 are associated with the development of asthma in Chinese children.
|
28262390 |
2018 |
Asthma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal region 17q12-q21 is associated with asthma and harbors regulatory polymorphisms that influence expression levels of all five protein-coding genes in the region: IKAROS family zinc finger 3 (Aiolos) (IKZF3), zona pellucida binding protein 2 (ZPBP2), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and gasdermins A and B (GSDMA, GSDMB).
|
28241063 |
2017 |
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
A meta-analysis of genome-wide association studies of asthma in Puerto Ricans.
|
28461288 |
2017 |
Asthma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
In the Swedish Search study, we found significant differences in DNA methylation between asthmatics and controls in five CpG sites; after adjusting for lymphocyte and neutrophil cell counts, three remained significant: one in IKZF3 [IKAROS family zinc finger 3 (Aiolos); cg16293631] and two in the CpG island (CGI) of ORMDL3 (cg02305874 and cg16638648).
|
25256354 |
2015 |
Asthma
|
0.460 |
Biomarker
|
disease |
CTD_human |
In the Swedish Search study, we found significant differences in DNA methylation between asthmatics and controls in five CpG sites; after adjusting for lymphocyte and neutrophil cell counts, three remained significant: one in IKZF3 [IKAROS family zinc finger 3 (Aiolos); cg16293631] and two in the CpG island (CGI) of ORMDL3 (cg02305874 and cg16638648).
|
25256354 |
2015 |
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study.
|
24406073 |
2014 |
Asthma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the strong allelic association between SNPs in the 17q21 region and asthma in Latinos (IKZF3, lowest P value: rs90792, odds ratio, 0.67; 95% CI, 0.61-0.75; P = 6 × 10(-13)) and replicated associations in several genes that had previously been associated with asthma in genome-wide association studies.
|
24406073 |
2014 |
Asthma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
We found 2 SNPs (1 novel rs9635726 in IKZF3) to be associated with asthma.
|
23622005 |
2013 |
Asthma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Sixteen SNPs were significantly associated with asthma after multiple testing correction (P ≤ .01), of which 5 (rs2290400, rs8079416, rs3894194, rs7212938, and rs3859192) were strongly associated (FDR P ≤ .0002), and one was novel (IKZF3-rs1453559).
|
22626592 |
2012 |
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
Asthma
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |