MMRN1, multimerin 1, 22915

N. diseases: 272; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.050 Biomarker disease BEFREE Liver cirrhosis (LC) is a disease characterized by pathological accumulation and alteration of extracellular matrix (ECM) proteins; the interaction between two such proteins, collagen and vitronectin (VN), is considered to be the key to controlling ECM remodeling in liver cirrhosis. 30984549 2019
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.050 Biomarker disease BEFREE Liver fibrosis, a precursor to cirrhosis, is the result of the deposition of extracellular matrix (ECM) proteins and is mediated primarily by activated hepatic stellate cells (HSCs). 28656203 2017
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.050 Biomarker disease BEFREE In particular, the interactions of ECM proteins with integrin receptors are key mediators of these cellular processes, playing a crucial role in the progression of several diseases of the liver, including inflammation, fibrosis/cirrhosis and cancer. 28963535 2017
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.050 Biomarker disease BEFREE Hepatic fibrosis (HF), a wound-healing response to a variety of chronic stimuli, is characterized by the excessive synthesis of extracellular matrix (ECM) proteins by hepatic stellate cells (HSC) and eventually the development of hepatic cirrhosis. 27633729 2016
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.050 Biomarker disease BEFREE The excessive synthesis of ECM proteins deteriorates hepatic architecture and results in liver fibrosis and cirrhosis. 17415633 2007