|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Molecular, structural, and functional aspects of FOXD1 are presented in light of physiological and pathogenic conditions, including its role in human disease aetiology, such as cancer and recurrent pregnancy loss.
|
29959475 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of FOXD1 is observed in glioma, lung cancer and breast cancer.
|
29864920 |
2018 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data verifies that lncRNA POU3 F3, induced by transcription factor SP1, acts as an oncogene in the cervical cancer tumorigenesis via regulating miR-127-5p/FOXD1 axis, providing a possible therapeutic target for cervical cancer.
|
31252264 |
2019 |
|
Diphtheria
|
0.010 |
Biomarker
|
disease |
BEFREE |
We crossed mice expressing Cre-recombinase under the FoxD1 promoter to Rosa26-loxP-STOP-loxP-iDTR mice and generated a bitransgenic line (FoxD1-Cre;Rs26-iDTR) in which FoxD1-derived cells heritably express simian or human diphtheria toxin receptor and are sensitive to DT.
|
27779900 |
2017 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that FOXD1 may serve as a novel regulator of glioblastoma cell behavior that may offer a novel target for gene targeted glioma therapies.
|
28075458 |
2017 |
|
Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inactivation of MAP3K7 in FOXD1-expressing cells results in loss of mesangial PDGFRΒ and juvenile kidney scarring.
|
29667914 |
2018 |
|
Hodgkin Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we screened six Hodgkin lymphoma (HL) cell lines for FOX gene activity by comparative microarray profiling, revealing overexpression of FOXC1 and FOXD1, and reduced transcription of FOXN3, FOXO1, and FOXP1.
|
25043849 |
2014 |
|
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In our study, we show that the neural crest-associated transcription factor FOXD1 plays a key role in the invasion and the migration capacities of metastatic melanomas both in vivo and in vitro.
|
30110134 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
FOXD1 Promotes Cell Growth and Metastasis by Activation of Vimentin in NSCLC.
|
30562753 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings reveal YAP-FOXD1, a novel aging-associated regulatory axis, as a potential target for gene therapy to alleviate osteoarthritis.
|
30933975 |
2019 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that FOXD1 might play key roles in OS development and progression, and was negatively regulated by miR-30a-5p in OS.
|
29936179 |
2018 |
|
Pneumonia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Low-dose DT reduced lung PDGFRβ<sup>+</sup> stromal cells in the FoxD1-Cre;iDTR transgenic model without a differential effect on lung inflammation in DT-sensitive and DT-insensitive animals.
|
27779900 |
2017 |
|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we demonstrate that deletion of CFIm25 in fibroblasts or myofibroblast precursors using either the Col1a1 or the Foxd1 promoter enhances pulmonary fibrosis after bleomycin exposure in mice.
|
30830875 |
2019 |
|
Ureteral obstruction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of Klf15 in Foxd1-expressing cells (Foxd1-Cre Klf15fl/fl) increased extracellular matrix deposition and myofibroblast proliferation as compared to wildtype (Foxd1-Cre Klf15+/+) mice after three and seven days of ureteral obstruction.
|
28651950 |
2017 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Autophagy in FOXD1 stroma-derived cells regulates renal fibrosis through TGF-β and NLRP3 inflammasome pathway.
|
30545632 |
2019 |
|
Adult Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we screened six Hodgkin lymphoma (HL) cell lines for FOX gene activity by comparative microarray profiling, revealing overexpression of FOXC1 and FOXD1, and reduced transcription of FOXN3, FOXO1, and FOXP1.
|
25043849 |
2014 |
|
Childhood Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we screened six Hodgkin lymphoma (HL) cell lines for FOX gene activity by comparative microarray profiling, revealing overexpression of FOXC1 and FOXD1, and reduced transcription of FOXN3, FOXO1, and FOXP1.
|
25043849 |
2014 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, FOXD1 is a direct target of miR-30a-5p and the miR-30a-5p/FOXD1/ERK axis may play an important role in the development of gemcitabine resistance in pancreatic cancer.
|
31602254 |
2019 |
|
Hereditary pancreatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we report that loss of the tumor suppressor gene Tsc2 in pericytes using a FoxD1 promoter driven cre allele (Foxd1tm1(GFP/cre) Amc, FoxD1GC) leads to the formation of HPC in multiple sites.
|
30124871 |
2018 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrated that FOXD1 and Gal-3 form a positive feedback loop in lung cancer, and interference of this loop may serve as an effective therapeutic target for the treatment of lung cancers, particularly those related to dysregulation of Gal-3.
|
31795213 |
2019 |
|
Intestinal metaplasia of gastric mucosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Suppression of miR-92a-1-5p and restoration of FOXD1 may be a preventive approach for gastric IM in patients with bile regurgitation.
|
30635407 |
2019 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that FOXD1 may serve as a novel regulator of glioblastoma cell behavior that may offer a novel target for gene targeted glioma therapies.
|
28075458 |
2017 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that FOXD1 may serve as a novel regulator of glioblastoma cell behavior that may offer a novel target for gene targeted glioma therapies.
|
28075458 |
2017 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data verifies that lncRNA POU3 F3, induced by transcription factor SP1, acts as an oncogene in the cervical cancer tumorigenesis via regulating miR-127-5p/FOXD1 axis, providing a possible therapeutic target for cervical cancer.
|
31252264 |
2019 |
|
Clear cell sarcoma of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
FOXD1 which identifies cells giving rise to stromal elements, and CITED1, a marker for cells primed for nephrogenic epithelial differentiation, were both highly expressed in CCSK.
|
24488803 |
2014 |