Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Xenograft tumor in nude mice was used to determine the effect of TPX2 in OC cells in vitro.
|
29904936 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, we validated p100 as a direct target of miR-320a, a tumor suppressing microRNA repressing lung cancer cell migration.
|
29159900 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RNAi was used for TPX2 protein expression knockdown, and a clonogenic assay, immunostaining, double thymidine block, image-cytometry analysis, and tumor spheroid assay were used to analyze the role of TPX2 in tumor cell growth, cell cycle progression, multinuclearity, ploidy, and tumorigenicity, respectively; finally, Western blotting was used to analyze anticancer mechanisms in TPX2 targeting.
|
28761362 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, we demonstrated that CD34-positive microvessels were significantly reduced in tumors treated with TPX2 siRNA compared to tumors that treated with Control siRNA.
|
25914189 |
2015 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TPX2 expression was found to be significantly higher in MTC compared to normal thyroid tissues (P < 0.05), and to be associated with tumor size, lymph node metastasis, and advanced disease stage.
|
24488334 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results demonstrated that TPX2 is important in the regulation of tumor growth in cervical cancer and therefore may be a potential therapeutic target as a novel treatment strategy.
|
24718984 |
2014 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Similar results were obtained by in vivo transplantation, as TPX2 siRNA transfection significantly reduced tumor growth of the xenograft in nude mice.
|
25239289 |
2014 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Upregulation of the TPX2 gene is associated with enhanced tumor malignance of esophageal squamous cell carcinoma.
|
23725757 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We observed a significant association of tumor proliferation, defined by Ki67 and mitotic index (MI), with both CIN4 expression and aneuploidy.
|
23468873 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Five genes from this cluster (CKAP5, KPNB1, RAN, TPX2, and KIF11) were evaluated in more detail and have been shown to be essential for tumor cell survival in both tumor types, but most particularly in HNSCC.
|
23444224 |
2013 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The DNA copy number and expression of the TPX2 gene were surveyed in pancreatic cancer cell lines and tumor tissues and compared with those of immortalized normal pancreatic ductal cells and normal pancreatic tissues.
|
19861455 |
2009 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Inhibiting RelB in aggressive androgen-independent PC-3 cells by stable or conditional expression of a dominant-negative p100 mutant significantly reduced the incidence and growth rate of tumors.
|
19351823 |
2009 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A repp86 labeling index (RI) of more than 10% positive tumor cells significantly predicted a shortened disease-free interval and an increased tumor mortality (both P <.0001).
|
12721258 |
2003 |