TPX2, TPX2 microtubule nucleation factor, 22974

N. diseases: 122; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis. 31272499 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE Moreover, TPX2 depletion led to prostate cancer cell growth inhibition, increased apoptosis, and reduced tumorigenesis. 28761362 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability. 28638452 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers. 25830658 2015
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC. 25632068 2015
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE These findings suggest that TPX2 plays an important role in promoting tumorigenesis and metastasis of human colon cancer, and may represent a novel prognostic biomarker and therapeutic target for the disease. 24341487 2013
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 AlteredExpression phenotype BEFREE The present study appraised the significance of TPX2 aberrant expression for tumorigenesis and progression of human squamous cell carcinoma (SCC) in lung. 16489064 2006