FOXC2, forkhead box C2, 2303

N. diseases: 168; N. variants: 18
Disease: Varicosity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042345
Disease: Varicosity
Varicosity 		0.160 AlteredExpression disease BEFREE The human varicose veins showed thickened intima, media and adventitia layers, increased synthetic VSMCs, as well as upregulated FOXC2-AS1 and FOXC2 expression. 31801629 2019
CUI: C0042345
Disease: Varicosity
Varicosity 		0.160 Biomarker disease BEFREE We hypothesized that an altered FoxC2-Dll4 signaling underlies saphenous vein wall remodeling in patients with varicose veins. 26808710 2016
CUI: C0042345
Disease: Varicosity
Varicosity 		0.160 GeneticVariation disease BEFREE Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians. 26420053 2016
CUI: C0042345
Disease: Varicosity
Varicosity 		0.160 Biomarker disease BEFREE Our study indicates altered FoxC2-Notch signaling in saphenous vein wall remodeling in patients with varicose veins. 24608096 2014
CUI: C0042345
Disease: Varicosity
Varicosity 		0.160 GeneticVariation disease BEFREE The fact that there is linkage to a candidate marker for the FOXC2 gene suggests there is a functional variant within, or in the vicinity of, which predisposes to varicose veins. 22664280 2012
CUI: C0042345
Disease: Varicosity
Varicosity 		0.160 GeneticVariation disease BEFREE Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. 15744037 2005
CUI: C0042345
Disease: Varicosity
Varicosity 		0.160 Biomarker disease HPO