Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Infiltrating duct carcinoma of female breast
0.300 GeneticVariation disease UNIPROT
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE For in vivo antitumor studies, the tumor growth rate of mice treated with DTX-loaded <sup>D</sup>T7-LIP was significantly inhibited compared to that in mice treated with DTX-loaded <sup>L</sup>T7-LIP and DTX-loaded Tf-LIP. 30395963 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE In summary, these findings illustrate that SMG-1 is suppressed by miR-192 and-215 and functions as a tumor suppressor in GC by inactivating Wnt signaling and suppressing EMT. 29239144 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE In vitro studies show that low oxygen increases hepatocellular ATX expression and transcriptome analysis showed a positive correlation between ATX mRNA levels and hypoxia gene score in HCC tumour tissue associated with HCV and other aetiologies. 28126468 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE Knock down of the expression of SMG-1 inhibited tumor cell proliferation and induced the chemosensitivity of pancreatic cancer cells in vitro. 25760059 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE In conclusion, our results indicate that SMG1 acts as a potential tumor suppressor with epigenetic regulation in AML. 25257528 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE Further study showed that SMG-1 expression was exactly associated with tumor differentiation and clinical stage in HCC. 24700316 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Given an increased tumor growth following depletion of SMG-1, our data demonstrate a novel role for SMG-1 in regulating Cdc25A and suppressing oncogenic CDK2 driven proliferation, confirming SMG-1 as a tumor suppressor. 24107632 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE An important player in the DDR, SMG-1 (suppressor with morphogenetic effect on genitalia), is a potential tumor suppressor and may therefore be deregulated in cancer. 22247495 2012
CUI: C0200635
Disease: Lymphocyte Count measurement
Lymphocyte Count measurement
0.100 GeneticVariation phenotype GWASDB The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes. 22286170 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 GeneticVariation disease GWASDB Genome-wide association study identifies five new schizophrenia loci. 21926974 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Autotaxin (ATX/NPP2) is a tumor cell motility-stimulating factor that displays both a nucleotide pyrophosphatase/phosphodiesterase activity and a recently described lysophospholipase D (lysoPLD) activity. 15027116 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE Although the inter-patient variability was large, we found that LIP, the isoform of C/EBPbeta known to inhibit transcription, was expressed at higher levels in Duke's stage B tumors compared with Duke's stage A, whereas Duke's C tumors had the lowest LIP expression. 10760820 2000
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 GeneticVariation group BEFREE In mice, total loss of SMG1 is embryonic lethal and loss of a single allele results in an increased rate of cancer development, particularly haematopoietic cancers and lung cancer. 31565865 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 Biomarker group BEFREE Recent accumulating evidence indicates the biological actions of Autotaxin-Lysophosphatidic acid (ATX-LPA) signaling axis in malignant tumors. 30921203 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 Biomarker group BEFREE ATX is a novel player in the pathogenesis of liver fibrosis and cancer and a promising therapeutic target.(Hepatology 2017;65:1369-1383). 27981605 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 AlteredExpression group BEFREE Here, we report for the first time, that the truncated CCAAT-enhancer-binding protein β (C/EBPβ) LIP isoform is abnormally overexpressed and correlated with cancer metastasis in clinical specimens of human ESCC. 24994936 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 AlteredExpression group BEFREE No studies have yet been conducted linking defects in SMG-1 expression with cancer. 22247495 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 Biomarker group BEFREE In the present article, we review some of the key findings that make the ATX-LPA signalling axis an emerging target for cancer therapy. 22260662 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 AlteredExpression group BEFREE The transcription factor C/EBPbeta may be involved in malignancy with its alternative translation product C/EBPbeta-LIP. 19958352 2010
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 GeneticVariation group BEFREE In mice, total loss of SMG1 is embryonic lethal and loss of a single allele results in an increased rate of cancer development, particularly haematopoietic cancers and lung cancer. 31565865 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 Biomarker group BEFREE ATX is a novel player in the pathogenesis of liver fibrosis and cancer and a promising therapeutic target.(Hepatology 2017;65:1369-1383). 27981605 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 AlteredExpression group BEFREE Here, we report for the first time, that the truncated CCAAT-enhancer-binding protein β (C/EBPβ) LIP isoform is abnormally overexpressed and correlated with cancer metastasis in clinical specimens of human ESCC. 24994936 2014
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 AlteredExpression group BEFREE No studies have yet been conducted linking defects in SMG-1 expression with cancer. 22247495 2012
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 Biomarker group BEFREE In the present article, we review some of the key findings that make the ATX-LPA signalling axis an emerging target for cancer therapy. 22260662 2012