|
Alveolar rhabdomyosarcoma
|
0.800 |
Biomarker
|
disease |
HPO |
|
|
|
|
Alveolar rhabdomyosarcoma
|
0.800 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Alveolar rhabdomyosarcoma
|
0.800 |
FusionGene
|
disease |
ORPHANET |
|
|
|
|
Diffuse Large B-Cell Lymphoma
|
0.350 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Somatic mutation
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Alveolar rhabdomyosarcoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
These assays detect PAX3-FKHR and PAX7-FKHR chimeric transcripts in alveolar rhabdomyosarcoma, EWS-FLI1 and EWS-ERG chimeric transcripts in Ewing's sarcoma, and EWS-WT1 chimeric transcripts in desmoplastic small round cell tumor.
|
7530783 |
1995 |
|
Alveolar rhabdomyosarcoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Alveolar rhabdomyosarcoma (ARMS) is characterized cytogenetically by a t(2;13)(q35;q14) chromosomal translocation involving two transcription factor genes: PAX3 and FKHR.
|
7624119 |
1995 |
|
Alveolar rhabdomyosarcoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.
|
7862145 |
1995 |
|
Alveolar rhabdomyosarcoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization.
|
7536457 |
1995 |
|
Alveolar rhabdomyosarcoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Using pulsed-field and fluorescence in situ hybridization analyses, we demonstrate that the 130kb FKHR intron 1 is rearranged in t(2;13)-containing alveolar rhabdomyosarcomas.
|
8634710 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, two of these genes have been found to produce neoplasia (qin and FKHR).
|
7576194 |
1995 |
|
Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sequential immunoprecipitations with anti-PAX3 and anti-FKHR sera demonstrated expression of a 97-kDa PAX3-FKHR fusion protein in the t(2;13)-positive rhabdomyosarcoma Rh30 cell line and verified that a single polypeptide contains epitopes derived from each protein.
|
7862145 |
1995 |
|
Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Translocation of the 5' region of the FKHR gene to the derivative chromosome 2, and retention of the 3' region of FKHR on the derivative chromosome 13 [(der(13)], were demonstrated in metaphase cells from a rhabdomyosarcoma cell line with a previously identified t(2;13) translocation.
|
7536457 |
1995 |
|
Childhood Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sequential immunoprecipitations with anti-PAX3 and anti-FKHR sera demonstrated expression of a 97-kDa PAX3-FKHR fusion protein in the t(2;13)-positive rhabdomyosarcoma Rh30 cell line and verified that a single polypeptide contains epitopes derived from each protein.
|
7862145 |
1995 |
|
Childhood Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Translocation of the 5' region of the FKHR gene to the derivative chromosome 2, and retention of the 3' region of FKHR on the derivative chromosome 13 [(der(13)], were demonstrated in metaphase cells from a rhabdomyosarcoma cell line with a previously identified t(2;13) translocation.
|
7536457 |
1995 |
|
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Translocation of the 5' region of the FKHR gene to the derivative chromosome 2, and retention of the 3' region of FKHR on the derivative chromosome 13 [(der(13)], were demonstrated in metaphase cells from a rhabdomyosarcoma cell line with a previously identified t(2;13) translocation.
|
7536457 |
1995 |
|
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sequential immunoprecipitations with anti-PAX3 and anti-FKHR sera demonstrated expression of a 97-kDa PAX3-FKHR fusion protein in the t(2;13)-positive rhabdomyosarcoma Rh30 cell line and verified that a single polypeptide contains epitopes derived from each protein.
|
7862145 |
1995 |
|
Childhood Alveolar Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma.
|
8634710 |
1995 |
|
Childhood Alveolar Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization.
|
7536457 |
1995 |
|
Childhood Alveolar Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These assays detect PAX3-FKHR and PAX7-FKHR chimeric transcripts in alveolar rhabdomyosarcoma, EWS-FLI1 and EWS-ERG chimeric transcripts in Ewing's sarcoma, and EWS-WT1 chimeric transcripts in desmoplastic small round cell tumor.
|
7530783 |
1995 |
|
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Alveolar tumors, for example, often possess a chromosomal translocation [t(2;13)(q35;q14)] that fuses the PAX3 gene in band 2q35 with the FKHR gene in band 13q14, creating a novel chimeric protein that could inappropriately activate normal targets of the PAX3 gene product, thereby contributing to tumorigenesis.
|
7636557 |
1995 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data demonstrate that PAX3 and PAX3-FKHR contain structurally distinct transcriptional activation domains and suggest that a consequent difference in function is important for oncogenesis.
|
7624119 |
1995 |
|
Sarcoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The PAX3-FKHR FISH assay was then applied to a series of cytogenetically characterized pediatric sarcoma cell lines.
|
7536457 |
1995 |
|
Malignant neoplasm of soft tissue
|
0.090 |
Biomarker
|
group |
BEFREE |
The PAX3-FKHR FISH assay was then applied to a series of cytogenetically characterized pediatric sarcoma cell lines.
|
7536457 |
1995 |
|
Ewings sarcoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
By combining the PAX3/FKHR RT-PCR assay with primers for detection of the Ewing's sarcoma t(11;22) encoded EWS/FLI-1 chimeric transcript, we have developed a multiplex RT-PCR reaction that allows the rapid and accurate identification of either translocation in a biopsy sample.
|
7887445 |
1995 |